Another giant followed suit, and one shot was five ＂Wang Huiwen＂

Recently, SaaS giant Salesforce announced the launch of a $250 million fund, which is by far the largest AIGC venture capital fund.

In this regard, CEO Clara Shih said that the fund will focus on "cultivating the next generation of artificial intelligence startups".

Some analysts also said that although the generative AI like ChatGPT itself amazed the public. However, their greatest role in the enterprise lies in their combination with the company’s business, which is obviously the goal of Salesforce.

However, judging from today’s stock price performance, the heavy AI did not make this old SaaS manufacturer dead.

250 million US dollars, which has exceeded the net profit of last year.

Different from VC’s pursuit of high returns, as a typical CVC, Salesforce chose to set up the fund at this time more likely because of industry competition and stock price considerations.

We saw that the foundation of the fund was announced at its annual conference TrailblazerDX. At that time, the company announced three major initiatives in generating artificial intelligence:

First, Salesforce is integrating generative artificial intelligence into customer relationship management products under Einstein GPT. These new features are designed to combine the data in Salesforce with a series of generative AI engines (including engines from OpenAI and Cohere), so that customers can seize the initiative in making marketing emails, writing supporting articles and even making computer code.

Second, Salesforce announced its cooperation with OpenAI, which makes ChatGPT available directly from Slack. This function is currently in the testing stage and will be launched on a large scale later this year.

Third, Salesforce Ventures is launching a $250 million investment fund to support generative AI startups.

There are several backgrounds that have to be mentioned behind these three measures.

First of all, on the eve of releasing its new AI product, Salesforce released a survey result, which showed that although some IT leaders expressed concern about AI, most people thought it could help them better support customers and improve data insight. Even 67% of the respondents said that they would give priority to this technology in the next 18 months, and one-third of the respondents thought it would be their top priority.

At the same time, Salesforce believes that it has identified several areas where artificial intelligence is reshaping the sales pattern: artificial intelligence insight of sales, natural language chat robots for service requests, targeted marketing content and personalized e-commerce experience.

Secondly, at the end of last year, after OpenAI’s ChatGPT broadened the imagination of the technology industry, many large companies rushed to announce the function of using artificial intelligence to generate content. Last month alone, Microsoft integrated OpenAI technology into Bing, Google announced the launch of ChatGPT competitor Bard, Meta released one of its large language models under the open source license, and Snapchat launched a social generation tool.

In addition, Microsoft recently launched Dynamic 365 Copilot, a functional assistant tool for customer relationship management (CRM) and enterprise resource planning (ERP) based on artificial intelligence, which directly extended its hand to the territory of traditional enterprise software platforms such as Zoho, Salesforce and IBM.

A consensus in the field of science and technology is that it is often fatal to miss the first advantage of technology, so we have seen Salesforce’s heavy investment in AI.

More importantly, the deployment of AI and the launch of Slack’s new ChatGPT application are at a critical moment when the board members of Salesforce are replaced, and investors have been pushing for new changes. Even at the beginning of this year, the company cut 10% of its employees.

As we all know, affected by the macro-environment, the market value of American SaaS companies suffered a decline in different degrees in 2022, and Salesforce was not spared. Salesforce is also under pressure from investors. Using the white-hot trend of generating artificial intelligence can help companies resist concerns about their growth prospects.

It is worth mentioning that at the beginning of this month, Salesforce released the latest financial report data. According to the financial report, the revenue of Salesforce in fiscal year 2023 was $31.4 billion, an increase of 18% year-on-year. However, the income growth rate has slowed down this fiscal year. Its revenue in the fourth quarter of fiscal year 2023 was $8.4 billion, a year-on-year increase of 14%, which was lower than the annual growth rate.

In terms of profit, salesforce’s operating profit in fiscal year 2023 was $1 billion, compared with $500 million in the previous fiscal year, which was significantly improved this fiscal year. This fiscal year, the company’s net profit was $200 million, compared with $1.4 billion in the same period of the previous fiscal year, and the net profit in the latest fiscal year decreased by 86%.

It can be seen that the scale of the AIGC fund has exceeded the net profit of Salesforce last year, which can be seen from the investment.

According to public data, Wall Street analysts agreed that earnings per share (EPS) in the fourth quarter was $1.36. However, the company reported earnings per share of $1.68, far exceeding expectations. In addition, the average income of analysts is estimated to be about $8 billion, while the company’s revenue in the fourth quarter was $8.4 billion.

But despite the amazing revenue growth of Salesforce in recent years, it is expected to achieve the goal of reaching $50 billion in sales in fiscal year 2026. But its share price trend has been developing in the opposite direction. Since December 2020, the company’s share price has plummeted by nearly 30%.

It is not difficult to see that Salesforce is eager for the growth prospects of its performance.

The first four companies to be selected.

Back to Salesforce, the new fund itself. Although the fund is the largest fund of Salesforce Ventures, it is not the first dedicated AI fund. As early as 2017, it raised $50 million for the artificial intelligence innovation fund to support its Einstein artificial intelligence toolset.

According to PitchBook, Salesforce Ventures has participated in 140 venture capital transactions of artificial intelligence and machine learning startups, accounting for about 19% of its total investment so far.

John Somorjai, executive vice president of Salesforce enterprise development and Salesforce Ventures, said: "for more than ten years, Salesforce Ventures has been investing in high-potential enterprise technology business, and these initial investments of the fund to generate artificial intelligence companies are fully in line with this strategy."

In fact, in the past decade, Salesforce Ventures has raised more than a dozen funds, ranging in size from $50 million to $125 million, and has also launched a series of vertically specific investment funds, including funds targeting specific regions such as Japan or Canada.

But before, Salesforce Ventures usually invested in enterprise cloud startups. After all, such investments may become more important for this software company because of the restrictions on large-scale acquisitions. For example, it has invested in star companies such as Zoom and DocuSign, and invested heavily in Snowflake IPO.

It is precisely because of its huge transaction scale and strategic value that Salesforce Ventures has always been regarded as the king of SaaS unicorns. At the same time, some people think that it may continue this myth in the AI field.

It is reported that the fund has invested in four start-up companies: You.com, a upstart search engine, just launched the generation of artificial intelligence a few months ago; Anthropic, an AI startup founded by former employees of OpenAI and highly sought after by VC, developed ChatGPT；; Cohere, a natural language processing (NLP) startup that recently cooperated with Google; And a secret startup called Hearth.AI

Specifically, Richard Socher, the founder of You.com, is the former chief scientist of Salesforce. The company was founded in 2020, and launched the AI chat function YouChat in search engines before Google and Microsoft at the end of last year. In terms of financing, at the end of 2021, You.com completed a $20 million seed round of financing led by Marc Benioff, CEO of Salesforce, and then completed a $25 million series of financing in the middle of last year.

Anthropic was founded in January, 2021. The latest report shows that shortly after accepting hundreds of millions of dollars from Google, it recently completed a new round of financing of 300 million dollars. After this financing, the value of Anthropic reached 4.1 billion dollars. Earlier, Anthropic raised $704 million through Series A and Series B financing in 2022.

Similarly, Cohere was founded in 2019, mainly providing access to large-scale language models and natural language processing (NLP) tools through APIs. Cohere has raised $170 million so far, including $125 million in Series B financing last year and $40 million in Series A financing in 2021. Earlier this year, it was reported in Reuters that Cohere was in talks to raise hundreds of millions of dollars in a round of financing, and the valuation of this startup may exceed 6 billion dollars after the completion of financing.

As for Hearth.AI, it should have been established in May, 2022. Except that it is the next generation management system (CRM) shown on its official website, we have not found any more public information. (Text/Zhang Xue, source/investment network)

Liverpool have become accustomed to robbing the rich and helping the poor this season, and there is no victory against the newly promoted Red Army.

At 20:30 Beijing time, Bournemouth played Liverpool in the Premier League. In the first half, Billing scored a goal, in the second half, jota made a point, and Salah missed a penalty. In the end, Bournemouth defeated Liverpool 1-0. Liverpool have no chance to surpass Tottenham in the standings and still rank fifth, while Bournemouth escapes from the bottom.

Liverpool have finished all the Premier League away games against newly promoted horses this season, but they have failed to win any of these three games.

Liverpool drew 2-2 with Fulham and then lost 0-1 to Nottingham Forest.

According to statistics, Liverpool have lost two games in a row against the team at the bottom of the standings. The last game was lost to Wolves, the team at the bottom, 0-3 on February 4. This is also the first time that Liverpool have lost to the bottom team twice in a row since 2011, when the team lost to Wolves and West Ham United.

In addition, Squawka statistics show that Liverpool have five Premier League games starting at 12: 30 noon (local time) so far this season, and they have never won in five games and scored only two goals.

The results of these five games are as follows:

Fulham 2-2 Liverpool

Everton 0-0 Liverpool

Nottingham Forest 1-0 Liverpool

Liverpool 0-0 Chelsea

Bournemouth 1-0 Liverpool

Research says that artificial intelligence can help detect breast cancer and reduce the workload of doctors.

[Global Network Reporter Zhang Yang] Artificial intelligence has been increasingly applied to people’s lives. In the medical field, many medical institutions have begun to try to use artificial intelligence technology to assist doctors in diagnosis. Recently, according to foreign media reports, many medical institutions around the world began to experiment with artificial intelligence technology to assist in the diagnosis of breast cancer.

According to the report, Hungary was one of the first countries to adopt relevant technologies. Since 2021, at least five hospitals have used artificial intelligence technology to assist the detection of breast cancer.

In a study published in 2022, the researchers recorded the number of times breast cancer was identified in 250,000 scans using artificial intelligence programs, and found that this was almost consistent with the level of human radiologists, and the scanning results could be read faster. The conclusion of this study is that if this technology is incorporated into doctors’ daily work, it can effectively reduce the workload of radiologists.

According to a doctor who used an artificial intelligence application, he was shocked by the effectiveness of the artificial intelligence program, because he submitted some difficult cases he encountered in his career to artificial intelligence for diagnosis, and the program correctly identified cancer symptoms every time.

With the enhancement of artificial intelligence technology, artificial intelligence can gradually complete more complex tasks, and many companies have been committed to combining artificial intelligence technology with medical care for many years. For example, YiduCore, a medical intelligent brain independently developed by medical science and technology enterprises in China, is the accumulation of core technologies for many years and a highly competitive medical intelligent infrastructure.

By virtue of YiduCore’s powerful data processing and AI algorithm capabilities, as well as its accumulated medical knowledge, insights and disease models, Yidu Technology assists customers such as medical institutions to manage authorized data efficiently and with high quality, making uncountable data computable, and at the same time, through continuous iteration of independent learning, continuously accumulating and strengthening the modeled knowledge map, promoting real breakthroughs in clinical diagnosis and treatment, and further providing value in public health, research, diagnosis and treatment and other scenarios.

Regarding the application of artificial intelligence technology in the diagnosis and treatment of breast cancer, Yidu Technology told reporters that in a phase III study on the treatment of HER2-positive breast cancer patients conducted by its Happy Life Technology (HLT) in cooperation with a well-known domestic pharmaceutical company, Happy Life Technology implemented digital recruitment through artificial intelligence technology, accelerated the positioning of target patients, found HER2-positive breast cancer patients more quickly and accurately, and completed the recruitment of patients with the target number.

Although artificial intelligence technology is rampant, many doctors or experts in artificial intelligence also said that artificial intelligence technology can not replace doctors, but is only used for auxiliary medical care. For example, when a doctor has made an assessment of the condition, he can use artificial intelligence to review it to prevent the occurrence of missed diagnosis.

＂Out-of-the-box＂ has become a new outlet for ChatGPT entrepreneurship. Listen to what the entrants say.

ChatGPT-led artificial intelligence (AI) storm has become a new outlet, with Baidu, JD.COM, Tencent and other big companies scrambling for layout, Internet tycoons swarming in, and entrepreneurs eager to move. As OpenAI announced the API of ChatGPT model to the world, the market was completely ignited.

A month ago, Wang Huiwen, a billionaire and former co-founder of Meituan, started ChatGPT’s business with a "Hero Post". He invested 50 million US dollars to recruit wise men, and the slogan "Building China’s OpenAI" attracted countless attention as soon as it went out. Later, former Sogou CEO Wang Xiaochuan and former JD.COM Group Senior Vice President Zhou Bowen came out one after another. This wave of AI entrepreneurship has started in a mighty way.

Wang Shao, who is currently doing full-stack development, has long been keenly aware of the new entrepreneurial trend blown by ChatGPT. Since December last year, he has built his own application based on ChatGPT model. A few years ago, he worked in JD.COM, Jinshan and other big Internet companies.

Beside Wang Shao, like him, there are not a few entrepreneurs who feel this wave of technology. "Everyone’s response is very enthusiastic. In many communities, entrepreneurs are integrating the ChatGPT)API into their existing products, including bookkeeping and note-taking, or using the API to make new products. " In an interview with national business daily, he described it this way.

Abroad, entrepreneurs are also aiming at this new trend. Even silicon valley venture capitalists who are in the cold winter of science and technology have poured money into this frontier field. According to market analysis firm PitchBook Data Inc, global venture capital invested $1.3 billion in start-ups developing generative AI software through 78 transactions last year.

Entrepreneurs aim at "out of the box"

Wang Shao is one of the early entrepreneurs who entered the ChatGPT wave. HerAI, which he is developing, is a voice dialogue robot, in which many quick creation tools have been developed based on ChatGPT model, such as short video script, summary, weekly report generation, foreign language learning, cooking, programming and other functions.

He told reporters that HerAI was inspired by the famous movie Her. In this film, the hero Theodore and the artificial intelligence system OS1 have experienced a strange love.

Image source: HerAI

"At present, some users may not be very good at communicating with AI, so we have made these out-of-the-box tools." He said. "Based on the current ChatGPT model, plus some other fine-tuning training can achieve better results."

In foreign countries, the direction that entrepreneurs aim at is similar to that of Wang Shao. Bret Greenstein, a partner of PricewaterhouseCoopers, said (foreign entrepreneurs)Most discussions focus on the "out-of-the-box" characteristics of generative AI.Anyone can access a system for public use directly through the Internet.

Recently, the opening of the ChatGPT model API has ignited the enthusiasm of many developers, especially the news that OpenAI has reduced the cost by 90%. In Wang Shao’s words, "this is a very big change", because for developers, the initial investment in making applications based on this model is mainly the cost of accessing the API.

"OpenAI wants to be an inclusive company for the whole world. Its goal is very big, and the price of the model may drop later. The current price is basically 1000 Chinese characters, and the cost is about 3 cents. At present, such income should cover the cost. " He said.

Every reporter noticed that since ChatGPT became popular all over the world, batches of AIGC companies have sprung up like mushrooms after rain, and many previously established AIGC startups have begun to enter the eyes of investors.

Image source: screenshot of public information

Vertical direction should be used as the main track.

Domestically, venture capital opportunities related to ChatGPT include developing large-scale language models of ChatGPT, which are being done by major Internet companies such as Baidu, JD.COM, Tencent and Alibaba.

Before developing his own AI application, Wang Shao also worked in several Internet giants such as JD.COM, Jinshan and Qunar. Wang Shao told every reporter,In addition to directly studying similar models, big manufacturers also have business applications based on such models.In his view, big manufacturers have their own advantages in making models similar to ChatGPT in China.

"ChatGPT can be regarded as a platform for content text output, and each country has different requirements for its own content security policy. If it is a language model, it has advantages from the domestic point of view. In addition, the model can also be particularly optimized for the Chinese environment. "

butFor the vast majority of entrepreneurs, Wang Shao believes that vertical application based on ChatGPT model is a more feasible direction.

"Most (entrepreneurs) are based on the ChatGPT model, making their own applications, fine-tuning them, and then combining them with products in their own industries, such as education, finance, insurance, and intelligent customer service." Wang Shao told every reporter.

Based on the foreign situation, Bret Greenstein also believes that if the enterprise data is used to fine-tune the basic language recognition model of such tools, countless enterprise software applications can be established.

In Wang Shao’s view, only companies with financial and technical confidence can develop their own models, and it may be difficult for startups to seize this opportunity. "If you make a (large language) model, it is only possible for head companies, such as Baidu and Ali, or companies that can continue to get large investments, because it burns money." He explained.

In fact, before the publication of ChatGPT, domestic AI startups based on the big model field have emerged one after another. Some startups have previously accessed the APIs of other language models (such as Curie, etc.) to explore the establishment of their own ecology. When ChatGPT has become a hot spot of global capital chasing, at this time, how to choose such startups will become a difficult problem?

Wang Shao believes that for these startups, embracing the new model or continuing to develop on the existing ecology may exist at the same time.

"ChatGPT is a general model. For some professional knowledge of specific industries, such as more professional grammar checking or virtual oral English teachers, it is still necessary to train separately. (These startups) can combine the original model with the ChatGPT model, and the functions that can’t be done can be handed over to ChatGPT, and the original functions can continue to be used. " He told reporters.

Subdivide the field to find opportunities

When Baidu, JD.COM, Tencent, Alibaba and other big companies entered the market, the entrepreneurial tide also swept through. How can entrepreneurs survive in the cracks without being squeezed out of the track by big companies? Wang Shao believes that the answer is obvious, and segmentation is the key.

"Large companies generally start with general-purpose products. At the beginning, they will not pay special attention to a certain sub-industry." He said. "(doing) entrepreneurial projects, you can cut in from a certain segment. When you achieve the ultimate in this subdivision, your accumulation of user needs is not easy to be directly copied. Then it will be more competitive to expand into other fields. "

"Because in essence, ChatGPT is a general model and is not good at certain fields. Many entrepreneurs have to specialize in a certain field and can only combine other AI models or fine-tune the model. " Wang Shao told reporters.

The reporter noted that in addition to HerAI, the first batch of entrepreneurs accessing ChatGPT API in China have begun to exert their efforts in various fields, such as cooking, education, shopping and so on.

Image source: RecipesAI

In Wang Shao’s imagination, he also intends to continue to explore in the segmentation field, for example, he plans to integrate more third-party AI services. HerAI has been online for several months. Judging from the user feedback he obtained, "the most appeal may be not limited to the output of words, but to directly generate PPT, tables and even videos."

ChatGPT’s east wind has indeed brought many opportunities, but to truly gain a foothold and play its own world, Wang Shao bluntly said that there are still great challenges, both technically and financially.

"Like I said,It is a great challenge to embed the third-party AI service directly into the conversational chat, which needs constant exploration and verification. In addition, there is a great demand for manpower and funds."He said.

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Harja believes that Daniel Jr. is suitable for Mourinho and lautaro correctly treats the ＂champion’s life＂

In spezia’s victory over Inter Milan, Daniel Jr. scored with Enzola, Lu Kaku scored a penalty and lautaro missed it. Paolo Maldini’s son is on loan to spezia, and his performance has improved. As the thickness of Milan’s lineup is not very good, Rossoneri fans hope that Daniel Jr will return to the San Siro. However, houssine kharja, a famous Inter Milan player, said that Daniel Jr.’ s playing method has no place under Pioli, and he won’t get a chance to start when he returns to Milan. Maldini should let his son continue his loan career. Harja believes that Daniel Junior is suitable for Mourinho, and if the youngster ends his loan career in spezia, he can go to Rome on loan. Mourinho needs all-rounders in the center and frontcourt. Daniel Jr. fits the requirements of famous Portuguese coaches, and Mourinho also likes players with excellent spiritual quality.

Although lautaro’s personal status fluctuates, he has a "championship life". He not only won the World Cup and America’s Cup with the Argentine team, but also won many championship trophies in the club. This is the "champion’s life", and Royce and Kane should be envious. However, Harja felt that after lautaro won so many championships, he neglected his personal promotion, which was not good for him. Therefore, Harja made a request-lautaro correctly treated the "champion’s life". In the first half of his career, the Argentine star won many collective honors, which was related to his good luck. After all, many players in his class, even many strikers who are better than him, have never tasted the championship.

"Champion life" can improve the confidence of players, and the team will regard itself as a "lucky star". Of course, this situation also has a negative effect. Players may rely too much on fate and neglect to improve their personal ability. Or because of his "championship life", he was burdened with heavy shackles and could not fulfill his personal talent, which was the trend in Gotze’s early career. Now Halja thinks that lautaro’s personal strength is in a stagnant state because of the championship, and his mentality is not very stable. He needs to treat and make good use of the "championship life" correctly, so that he can bring more glory to Inter Milan or the Argentine team. Halja also admitted that after Lu Kaku’s loan career ends, he probably won’t stay at the Meazza Stadium, and lautaro will have to take on more responsibilities in the front line.

As a descendant of Maldini family, Daniel Jr. can go out on loan, which is a breakthrough in Harja’s view. Aside from the emotional elements, Daniel Jr.’ s style of play and playing method are not suitable for Milan in Pioli’s era, but he is suitable for Mourinho. As we all know, Mu Shuai doesn’t pay much attention to the talent of young players, or the magic bird pays more attention to the attitude of players than aura. This model is very suitable for Daniel Jr. The two sons of the Cavaliers don’t seem to have inherited their father’s talent. In Harja’s view, talent itself is something that can’t be met. If Daniel Jr. changes to play in the back or centre-back according to what Ronaldinho said before, maybe his talent will be displayed. Since little Daniel wants to develop in the direction of attacking players, he needs better Bole.

Abraham has improved significantly under Mu Shuai, and even chaaraoui has a tendency to begin to understand again. If Daniel Jr. defected to a famous Portuguese coach, Harja believed that he would be greatly promoted in all aspects. Moreover, the football family has made Daniel Jr.’ s basic skills very solid, which is what Mourinho needs. Therefore, Harja stressed that Daniel Jr. is suitable for Mourinho. Of course, Halja also admitted that the "Milan gene" of the son of the Cavaliers will not change, and it is impossible for Pioli to coach the Rossoneri all the time. If Pioli leaves the San Siro in the future, Daniel Jr. can return to Milan and continue the glory of the Maldini family. The prerequisite of all this is that a famous coach needs to lay a good foundation for him, and Mu Shuai can become this role.

Lautaro emphasized in his previous interview that he has won many championships in these two seasons, and it seems that he particularly enjoys the experience brought by the "championship life". However, the author feels that he still lacks two important champions-the Champions League and the World Club Cup. According to the current strength of Inter Milan, there is still a big gap between the club and the top teams in the Champions League. In addition to marotta’s need to introduce more powerful players, lautaro’s generation of players should also strive to improve their personal ability and cooperation ability, so that he can truly realize his "lucky star" rhetoric. Thus, lautaro needs to treat the "champion’s life" correctly.

AI painted, and the effect is very good.

AI painting is getting closer and closer to everyone’s life, and the most direct manifestation is the "AI painting" filter in Tik Tok, which has recently caught fire on the Internet. It takes only a few seconds to upload your own photos, and the filter can automatically convert them into the corresponding secondary animation style.

Some renderings generated after the picture can be seen that although this AI painting filter can’t accurately restore the movements, costumes or facial features of characters, but the overall effect is quite good-the details of human body proportion, facial features and costume modeling are still very accurate, the colors are beautiful, and the depiction of light and shadow is also in place.

Different types of photos, found this. AI painting filter works best when dealing with a single photo. If there are multiple people overlapping or closely fitting in the uploaded picture, AI doesn’t seem to be able to identify them accurately. For the props held by cats, glasses or characters, this AI filter will directly choose "ignore"; There will even be problems such as gender mistakes and the collapse of painting style.

The problem did not cause dissatisfaction. On the contrary, many users shared their original pictures and the renderings of the cow’s head and the horse’s mouth, which attracted extensive onlookers from netizens. The contrast caused by the defects of AI program is unbearable, and everyone has said that this should not be called "artificial intelligence painting" but "artificial mentally retarded painting".

In addition to getting closer and closer to people’s work and lifeSome AI painting tools we are familiar with have also made great progress and improvement in performance.

(The article is reproduced inThe purpose of reprinting is to convey more information and share it on the Internet, which does not mean that this site agrees with its views and is responsible for its authenticity, nor does it constitute any other suggestions. If you find any works that infringe your intellectual property rights on the website, please write to us directly and we will modify or delete them in time. The pictures come from the internet, only for the content of the article, not for commercial use. )

Nature writes： In the next 30 years, cancer will cost the world 25 trillion US dollars.

Monoclonal antibody against B-cell psoriasis leukemia, a target of cancer artificial intelligence

①Nature：Cancer will cost the world $25 trillion over next 30 years

In the next 30 years, cancer may cost the world $25 trillion.

DOI :10.1038/d41586-023-00634-9

②Seminars in Cancer Biology：Artificial intelligence in cancer immunotherapy: applications in neoantigen recognition, antibody design and immunotherapy response prediction

Review: Application and development of artificial intelligence in the field of precision oncology: new antigen recognition, antibody design and immunotherapy response prediction.

DOI :10.1016/j.semcancer.2023.02.007

③Molecular Cancer：CD39/CD73/A2AR pathway and cancer immunotherapy

Review: New progress in pathophysiological function of CD39/CD73/A2AR pathway in cancer development, metastasis and drug resistance.

DOI :10.1186/s12943-023-01733-x

④Immunity：B cell receptor signaling in germinal centers prolongs survival and primes B cells for selection

B cell receptor signal transduction in germinal center prolongs the survival of B cells and initiates the selection of B cells.

DOI :10.1016/j.immuni.2023.02.003

⑤Frontiers in Immunology：Metabolic rewiring in keratinocytes by miR-31-5p identifies therapeutic intervention for psoriasis

The metabolic recombination of miR-31-5p in keratinocytes determines the intervention on psoriasis.

DOI :10.15252/emmm.202215674

⑥Journal of Hematology & Oncology：Novel agents and regimens in acute myeloid leukemia: latest updates from 2022 ASH Annual Meeting

The latest drug research and new scheme progress of American Society of Hematology (ASH) for acute myeloid leukemia (AML)
DOI :10.1186/s13045-023-01411-x

⑦FDA extended the review of adult Roctavian with severe hemophilia A because of "significant changes in a large number of additional data"

⑧ A small molecule MET inhibitor, gumetinib, which was developed by Shanghai Institute of Pharmacology, China Academy of Sciences, was approved for marketing, and it was used for locally advanced or metastatic non-small cell lung cancer (NSCLC) with the jump mutation (METex14 jump) in exon 14 of mesenchymal-epithelial transforming factor (MET).

⑨ The clinical study of Relma-cel targeting CD19 for first-line high-risk large B-cell lymphoma was officially launched.

⑩ Lilly will terminate the research and development of Solanezumab for Alzheimer’s disease because it fails to slow down the cognitive decline of preclinical Alzheimer’s patients.

The world of scientific exploration is full of challenges. AtaGenix pays tribute to every pioneer and is more committed to becoming your trusted partner!

Manchester United aim at Kane, Osman and Ramos, and prepare for the transfer window!

Manchester United are actively paying attention to harry kane, Osman and Ramos, and are preparing to try to sign one of them in the summer transfer window to enhance the team’s offensive strength.

It is reported that Manchester United coach Tenghahe has been looking for a world-class striker to strengthen the team’s attack line. Of the three players, harry kane is regarded as one of the most urgent targets. However, due to its high price, Manchester United will have to pay a huge price in the summer window.

In addition, Tenghahe is also paying attention to Napoli striker Osman and Benfica striker Ramos. Both players have performed well in the past season, and their value is relatively low, which has become a potential target for Manchester United.

It is worth mentioning that Manchester United are also looking for a new goalkeeper. As Manchester United goalkeeper Degea’s contract is about to expire, brentford goalkeeper Laia and Porto goalkeeper Costa are both considered. However, Raya will wait for the team to enter the Champions League before considering whether to renew the contract. Degea’s footwork and skill in distributing the ball frustrated team coach Tenghage. It is reported that Tenghahe has also begun to pay attention to the small Schumacher of Leicester City Gate and is ready to make an offer in the summer window.# Headline Creation Challenge #

Jose Mourinho will stay in the Champions League, Juventus will dig Chelsea goalkeeper, and Liverpool will chase Locatelli.

According to La Gazzetta dello Sport, whether you can get tickets for next season’s Champions League will largely determine whether Mourinho will leave Rome. On the other hand, Juventus are planning some transfer moves.

In the previous round, Rome lost 1-2 to cremona, which ranked second to last, and Mourinho got the third red card this season. At present, Rome ranks fourth in Serie A and has a chance to get tickets for next season’s Champions League. Roma are satisfied with Mourinho’s work and intend to renew his contract, but the madman is considering his choice. Rome is not a local tyrant club, so it can’t give much support on the transfer fee, and Mu Shuai is powerless.

It is reported that Mourinho’s stay will depend on whether Rome can reach the Champions League next season, which is a promise made by the madman to the club when he first entered the club. However, there are still many problems in Rome’s lineup, such as relying too much on Dibala. As long as the magic fairy does not play, others will not score. The current state of the team is not ideal, and the road ahead is full of difficulties.

Mourinho has received invitations from many clubs and Paris is said to be interested in him. By May, it will be two years since Mourinho came to Rome. This team has already left his deep mark, so it’s a pity to give up. Moreover, in terms of Mu Shuai’s character, he will not give up easily. However, the current situation is a bit complicated. If we fail to reach the Champions League, the possibility of cooperation between the two sides is not low.

On the other hand, after 15 points have been deducted, it can basically be concluded that Juventus will miss the Champions League next season, which will have a great impact on the club. Economically, Juve is facing a possible collapse, and it is inevitable that some players will leave the team, including some very important players.

According to reports, Juve are open to selling the big-name stars in the team. Vlahovic, chiesa Jr. and Locatelli are all transferable. Among them, Liverpool have taken a fancy to Locatelli and may buy it in the summer window. Liverpool are short of midfielders. Compared with Bellingham and caycedo, Locatelli is a "low-cost" choice.

It is reported that Arsenal may join the competition, and the prospect of Liverpool competing for the Champions League tickets is unpredictable, which may become a disadvantage. Previously, Juve spent 30 million yuan on the introduction of Locatelli. The player is 25 years old and is worth about 45 million yuan.

At the same time, Juve are ready to adjust their lineup, looking for a body double for szczesny and finding Mendi. Before that, Mendy played for a long time, but with Porter in Chelsea, Kepa was in a brave state and regained the main position. If the situation does not change, Mendy will leave the team in the summer window and Chelsea are willing to let him go. Under such circumstances, it is difficult for Chelsea to sell Mendi at a high price, and they can accept an offer of around 30 million.

A new breakthrough in the field of smart double carbon! Runhe Software Initiates Photovoltaic Panoramic Monitoring Integrated Machine

Recently, the first photovoltaic panoramic monitoring integrated machine independently developed by Jiangsu Runhe Software Co., Ltd. (hereinafter referred to as "Runhe Software") successfully landed. This product integrates multi-class platforms, realizes one-stop collaborative management, and pioneered the collaborative strategy algorithm of component cleaning artificial intelligence in the industry, which can reduce operating costs, improve power generation efficiency and transportation management level, and accelerate the process of digital intelligence of photovoltaic power stations.The successful delivery of the first all-in-one photovoltaic panoramic monitoring machine is an important step taken by Runhe Software in the field of smart double carbon and new energy, and it has achieved a new breakthrough in the industry..

The collaborative strategy algorithm of component cleaning artificial intelligence is the first in the industry, and the average power generation is increased by about 5%.

At present, distributed photovoltaic power plants are widely used on the roofs of parks and enterprises, but the photovoltaic modules are exposed to the outside for a long time, so some dirt such as floating ash, bird droppings and putty will be deposited on their surfaces during use, which reduces the effective area of photovoltaic modules to receive sunlight and seriously affects the working efficiency of power generation systems. At the same time, it is necessary to detect the dirty condition manually on a regular basis, which consumes a lot of manpower and material resources.

Runhe Software Photovoltaic Panoramic Monitoring All-in-One Machine has innovated the artificial intelligence identification algorithm for the cleanliness of components. Based on the artificial intelligence image identification technology, the algorithm can realize the real-time identification of the degree of dust accumulation and fouling of components, and at the same time, combine the future weather conditions and equipment operation state to comprehensively judge the cleaning opportunity, generate the cleaning and operation and maintenance strategy, and link the cleaning robot and spraying equipment to clean photovoltaic components, thus reducing the manual operation and maintenance cost and maximizing the working efficiency of the power generation system.According to statistics, after using the integrated photovoltaic panoramic monitoring machine, it is estimated that the annual power generation of photovoltaic power stations will increase by about 5% on average and the power generation efficiency will increase by about 1.5% on average..

Integrating 5+ platform to realize one-stop collaborative management

At present, the monitoring and operation system of distributed photovoltaic power plants has not been widely used. The power plants are faced with problems such as small scale of single station, scattered locations, insufficient operation and maintenance personnel, uneven operation and maintenance capabilities, and high operation and maintenance costs, which easily lead to management confusion and low operation and maintenance efficiency. At the same time, the existing photovoltaic power station management platform mostly focuses on power generation efficiency monitoring. At the operation and maintenance level, there is a lack of collaborative management and control of different manufacturers’ equipment and systems, and a lack of cross-domain integration of various equipment models. Customers need to log on to different platforms for data analysis and management in the station.

Runhe software photovoltaic panoramic monitoring integrated machine,The photovoltaic panoramic monitoring platform is used to integrate five different platforms, including photovoltaic power station management, energy efficiency management, charging pile management, energy storage management and auxiliary monitoring management.At the same time, it can be customized according to customer needs and increase the amount of platform integration. Through lean unified monitoring of equipment and automatic comprehensive judgment of operation and maintenance strategy, safe, efficient and reliable one-stop multi-platform collaborative management is realized, which greatly improves operation and maintenance efficiency.

Runhe Software Photovoltaic Panoramic Monitoring Integrated Machine Landing

To achieve high-quality operation and maintenance of photovoltaic power plants, the investment period can be shortened by half a year.

The operation and maintenance of photovoltaic power plants is the key point to ensure the photovoltaic industry to turn from high-speed growth to high-level stable operation. With the rapid growth of the capacity of distributed photovoltaic power plants in China, the traditional operation and maintenance mode needs to be changed to high-quality operation and maintenance characterized by more intelligence and refinement, so as to improve the power generation income of power plants and reduce the operation and maintenance investment.

Photovoltaic panoramic monitoring integrated machine can help photovoltaic power plants reduce costs and increase efficiency, and realize low investment and high return. After use, the all-in-one machine can save manual operation, space layout and procurement costs, and improve power generation efficiency.Based on the calculation of distributed photovoltaic power plants below 6MW, the investment of all-in-one machine can be realized in one year at the earliest, and the overall investment cycle of photovoltaic power plants can be shortened by about half a year..

Software and hardware are independently researched and developed, with more powerful functions and more convenient operation.

At present, Runhe Software’s first all-in-one photovoltaic panoramic monitoring machine has successfully landed at Jingda 7.9MW photovoltaic power station in Tongling, Anhui. As the core brain of panoramic monitoring and intelligent operation and maintenance of photovoltaic power plants, it has successfully realized the panoramic monitoring and intelligent management of operation and maintenance of photovoltaic power plants.

It is particularly worth mentioning that Runhe software investigates the real operation and maintenance needs of operators, average age, height and other factors, and creates the appearance design according to ergonomic innovation, making the hardware layout more reasonable, which will help the staff to operate the machine faster and more conveniently and improve the operation and maintenance efficiency.

Site Roof of Jingda 7.9MW Photovoltaic Power Station in Tongling, Anhui Province

In the future, Runhe Software will work with industrial chain partners to improve the overall function of the all-in-one photovoltaic panoramic monitoring machine. It is expected that this year, the monitoring system and optical power prediction system of photovoltaic power plants will be integrated, the management efficiency and operation mode of photovoltaic power plants will be innovated, the deep penetration and integration of the new generation of information technology and photovoltaic industry will be promoted, the digital transformation and intelligent upgrading of photovoltaic industry will be enabled, and the country will achieve the goal of double carbon and build a sustainable future together.