分类： sangna

　　Medical Guidance/Deng Minduan, Chief Physician of Gynecology and Obstetrics and Deputy Director of Gynecology and Pediatrics, Guangzhou Red Cross Hospital

　　In recent days, mainland women’s attention to HPV vaccine has been exploded again: first, the bivalent HPV vaccine was approved by the State Food and Drug Administration, and the vaccination age was relaxed from 9 to 25 years old to 9 to 45 years old; The next day, the nine-valent HPV vaccine, which was just approved in the mainland at the end of April, was listed in Boao, Hainan, and the listing of other provinces and cities in the mainland was just around the corner.

　　As a result, there are three different "price" HPV vaccines in the Mainland for women to choose and vaccinate. With more choices, there will be more natural entanglements: "At the age of bivalent and tetravalent, which one is better?" "I’ve been vaccinated with bivalent or tetravalent before, and now nine valence has come out. Is it necessary to go to ‘ Fill a needle ’ " ? Deng Minduan, chief physician of obstetrics and gynecology and deputy director of gynecology and pediatrics of Guangzhou Red Cross Hospital, analyzed all aspects of HPV vaccine for everyone.

　　Text/Guangzhou Daily All-Media Reporter Wu Wei Correspondent Hu Yingying

　　Bivalent and tetravalent can prevent 70% of cervical cancer, and nine valence can prevent 90%.

　　Deng Minduan introduced that there are currently three kinds of HPV vaccines listed at home and abroad, namely bivalent, tetravalent and nonavalent vaccines. In the second half of last year and the beginning of this year, the second price and the fourth price were listed one after another in the mainland of China, and the ninth price is about to be fully listed. Valence represents the number of HPV subtypes prevented: the more valences, the more HPV subtypes prevented, and the higher the preventive efficacy. The above three vaccines can prevent HPV16 and 18 subtypes from infection. These two subtypes of virus infection are the most common causes of cervical cancer, accounting for about 70%, so the incidence of cervical cancer can be significantly reduced after vaccination.

　　Compared with the first two vaccines, the nine-valent vaccine is different in that cervical cancer can be reduced by 70% after vaccination with bivalent vaccine; After vaccination with tetravalent vaccine, it can not only reduce 70% of cervical cancer, but also prevent 90% of genital warts (a common sexually transmitted disease); After inoculation with the nine-valent vaccine, the incidence of cervical cancer can be further reduced (it can reduce cervical cancer by 90%) on the basis of the four-valent vaccine, and it can also prevent genital warts by 90%.　　

　　If you are vaccinating bivalent or tetravalent vaccine now, can you switch to nine-valent vaccine to continue vaccination? Deng Minduan said that it is not recommended to mix and play. Different vaccines have different preparation processes, so it is recommended to continue vaccination according to the original plan. Then, I have been vaccinated with three doses of bivalent or tetravalent vaccine before. Is it necessary to vaccinate with nine-valent vaccine now? "Under normal circumstances, there is no need to vaccinate Jiujia. Because bivalent or tetravalent vaccine has a good effect of preventing cervical cancer, it can reduce cervical cancer by 70%, and the nine-valent vaccine only reduces cervical cancer by 20% on this basis. From the perspective of health economics, it is not necessary to vaccinate the nine-valent vaccine again. Of course, if the individual’s economic ability can afford it, it is another matter and you can consider it yourself. "

　　Key population of HPV vaccination: women aged 9-14.

　　Women who continue to pay attention to HPV vaccine will find that the applicable population of HPV vaccine in mainland China is different from other places. Deng Minduan explained that this was mainly because the age of the observed subjects in the clinical research before the vaccine was marketed in mainland China was different from that in other regions and countries. Therefore, it cannot be said that it is ineffective to vaccinate people outside the age specified in the instructions. However, before the instructions are updated, at present, vaccination can only be carried out in accordance with mainland regulations.

　　In fact, regarding the optimal vaccination age of HPV vaccine, the World Health Organization once pointed out in its position statement on HPV vaccine in May 2017: "The primary target population of HPV vaccine is women aged 9-14 before having sex for the first time". Because HPV virus is mainly transmitted through sex, the older you are, the higher the possibility of having sex, and the protective effect will be weakened after being vaccinated with HPV virus. In addition, the immune response of young women after vaccination is stronger than that of the elderly, and more antibodies are produced. Therefore, the focus of vaccination is on women aged 9-14 before their first sexual intercourse.

　　However, due to the different regulations on the applicable population of vaccines in mainland China, women aged 9-14 can only be vaccinated with bivalent vaccines for the time being.

　　According to the position statement of WHO in 2017, the protective effect lasts for at least 8-10 years after vaccination with bivalent and tetravalent HPV vaccines; After inoculation with nine-valent vaccine, the protective effect lasted for more than 5.6 years. Because the vaccine has not been on the market for a long time (especially the nine-valent vaccine), the related research is still going on, and maybe there will be a clearer statement in the future.

　　There is no need to test HPV before vaccination.

　　Some women think that it is necessary to test whether there is HPV infection before vaccination. In this regard, Deng Minduan said that it is not necessary, because the more the price of the vaccine, the more virus subtypes are prevented. In general, very few people are infected with virus subtypes that are completely consistent with the vaccinated vaccine. Therefore, even if one or two subtypes are infected, vaccination can still obtain the protection of other subtypes.

　　In addition, HPV can be repeatedly infected. Some studies have found that even if infected with a subtype of virus, or even caused cervical lesions, vaccination after treatment can reduce the recurrence rate of the disease. Therefore, it is not necessary to carry out HPV testing before vaccination.

　　However, if this woman happens to be at the time of cervical screening, or has never been screened, she can be screened at the same time as vaccination.

　　Deng Minduan introduced that HPV vaccine can be vaccinated during menstrual period, and you can have sex after vaccination, but it is recommended to use contraception temporarily until you have finished 3 shots and completed the whole vaccination procedure. If unexpected pregnancy is found during vaccination, it is recommended to stop vaccination immediately, and the remaining vaccines should be vaccinated after delivery and lactation. "Regarding the safety of pregnancy during HPV vaccination, the research data in this field in the world is extremely limited. According to the existing research data, the risk of adverse pregnancy events such as fetal congenital abnormalities and spontaneous abortion has not increased, but it is best not to vaccinate indirectly during pregnancy. " He said.

　　Deng Minduan reminded that no matter which "price" vaccine is vaccinated, cervical cancer screening should still be carried out regularly after vaccination. Because the current vaccines can’t prevent cervical cancer 100%, even the nine-valent vaccine only reduces cervical cancer by 90%.

　　Men can also be vaccinated against HPV.

　　Deng Minduan said that cervical cancer caused by HPV infection is the second largest malignant tumor in young women, but HPV infection is not a "patent" for women, and men will also be infected.

　　Comparatively speaking, the burden of male malignant tumors caused by HPV infection is lighter, such as penile cancer, anal cancer, oropharyngeal cancer, etc., and the incidence rate is lower. Therefore, the effect of male HPV vaccination on preventing male malignant tumors is not very significant.

　　However, the study found that after a certain proportion of men vaccinated with HPV vaccine, it will also have an effect on reducing the incidence of cervical cancer in women. In addition, because the tetravalent and nonavalent vaccines can also prevent genital warts (a common sexually transmitted disease, which affects both men and women), and there are more than 32 million new genital warts worldwide every year, the World Health Organization recommends that men be vaccinated with tetravalent or nonavalent vaccines. The FDA also approved men aged 9-26 to be vaccinated with HPV.

　　However, at present, the three kinds of HPV vaccines (bivalent, tetravalent and nine-valent) approved by the mainland do not include men among the applicable population. Therefore, if men want to vaccinate tetravalent or nine-valent HPV vaccines, they can only go to the relevant countries or regions that have approved male vaccination.

Since the 18th National Congress of the Communist Party of China, the General Secretary of the Supreme Leader has repeatedly stressed that leading cadres should be good at using the method of bottom line thinking, prepare everything from the bad and strive for the best results. In the history of the Communist Party of China (CPC), Mao Zedong is a strategic master who is good at using bottom line thinking. In his "conclusion" made at the Seventh National Congress of the Communist Party of China in May 1945, he listed "seventeen difficulties" that we might encounter in one breath in the face of the excellent situation of "victory" in the Anti-Japanese War, and put forward our countermeasures accordingly, which is a typical example of successfully using the bottom line thinking.

"We should build our policy on the worst possibility."

By the time the Seventh National Congress was held, great changes had taken place in the Communist Party of China (CPC). After Yan’ an rectification, the whole party realized a great awakening in thought and action, and achieved new unity and unity; It has become a powerful political party with rich experience and 1.21 million party member, and has become the focus of China people’s resistance to Japan and national salvation, the focus of China people’s liberation and the focus of defeating the aggressors and building a new China. The people’s army led by the Party has grown to 910,000, the militia to 2.2 million, and the population of the liberated areas to 95.5 million, and it has received assistance from the people of the whole country, people all over the world, especially the Soviet Union. In short, as Mao Zedong said, "the Communist Party of China (CPC) has never been so powerful, the revolutionary base areas have never had such a large population and such a large army, the Communist Party of China (CPC)’s prestige among the people in the Japanese and Kuomintang areas is also the highest now, and the revolutionary forces of the Soviet Union and the people of other countries are also the greatest now. Under these conditions, it should be said that it is entirely possible to defeat the aggressors and build a new China. "

The international and domestic situation is bright and beautiful, and the mast of "victory" seems to have jumped over the horizon. However, just as people were preparing to cheer loudly and celebrate the "victory", on May 31, Mao Zedong unexpectedly expressed his support for someone’s suggestion that China might become a semi-colony of the United States after the war in his seven "conclusions", stressing that it was necessary to "prepare for losses" and "prepare for difficulties" while seeing "light". He also listed the possible "seventeen difficulties" in one breath:

The first one is "foreign abuse". British and American newspapers and news agencies now scold communist party, "The more we develop in the future, the stronger they will scold". Second, "domestic abuse". It is a big curse, not a small one, calling us "sabotaging the war of resistance against Japan, endangering the country, killing and setting fires, communist hetaerism, being inhuman, and so on". Third, "they are going to occupy several large base areas." Article 4, "They wiped out tens of thousands of troops". In the future, our army is likely to grow to 1.5 million, leaving 1 million "one third lost by him"; He "got rid of half" and left 750 thousand. Article 5, "The puppet troops welcome Chiang Kai-shek". The puppet army "transformed itself, hung Chiang Kai-shek’s flag, welcomed Chiang Kai-shek and welcomed Yan Xishan, which made us very difficult." Where the Japanese withdrew, they immediately occupied it, and we were too late. " Article 6, "Civil War". Seventh, "out of Scobie, China becomes Greece" (Scobie was the British commander stationed in Greece at that time. In December 1944, Scobie commanded the British army and assisted the Greek government in attacking the Greek People’s Liberation Army, which had bravely resisted the Germans for a long time, and massacred the Greek patriotic people). That is to say, foreign forces interfered in China’s internal affairs and helped Chiang Kai-shek beat us. Article 8: "No recognition of Poland" means that the status of our party is "not recognized". Article 9, "Run away and scatter tens of thousands of party member". In the future, if the situation is not good, "Chiang Kai-shek and Scobie will be attacked from both sides, shooting everywhere, and some party member will turn back, run away and disperse." We’re going to disperse a third or more.Tenth, "pessimism and fatigue appear in the party." Eleventh, "natural disasters are prevalent, and the bare land is thousands of miles away." Article 12, "economic difficulties". Thirteenth, "the enemy forces are concentrated in North China". That is, "the Japanese army withdrew from South China and Central China and withdrew all its troops to North China", and "proposed the conditions of peaceful compromise and made peace with Britain and the United States", squeezing our party and the Eighth Route Army. Article 14, "The Kuomintang carried out an assassination plot to assassinate our responsible comrades". Article 15: "The leading organs of the Party have different opinions", and there are "many discussions, disagreement, dissatisfaction, etc." within the Party. Article 16, "The international proletariat will not help us for a long time". Article 17, "Other unexpected things".

When enumerating these difficulties, Mao Zedong also criticized that "there was a tradition in our party that we could not talk about difficulties, and always said that the enemy always collapsed and we were a great victory". "Now we must have full confidence to estimate the light and also have full confidence to estimate the darkness"."We should establish our policy in the worst possible way", especially for the senior responsible cadres of the Party, and we should be mentally prepared to deal with very difficult and unfavorable situations.He said:"If we are not prepared not to imagine such difficulties, we will not be able to deal with them when they come, but with such preparation, it will be easy to handle affairs."

"Don’t repeat the mistake of being proud when you win."

Faced with the bright future of "bright" and "victory", why did Mao Zedong pour a cold water head-on, talk about "seventeen difficulties" in one breath, and repeatedly emphasize "preparing for losses"? The reason why Mao Zedong did this is not aimless or posturing, but has profound historical and practical basis.

Historically, our party has made many mistakes because of "victory" and "loss" because of "pride", leaving a painful lesson. In order to prepare for the Seventh National Congress of the Communist Party of China, from 1943 to 1944, senior cadres of the whole Party seriously discussed the historical issues of the Party. On April 12, 1944, at the meeting of senior cadres in Yan ‘an and in the first lecture of the Central Party School on May 20, Mao Zedong made a systematic review and analysis of the party’s lessons in this regard, pointing out: "There have been several times in the history of our party that we have shown great pride and suffered losses." He listed four specific lessons: "The first time was in the first half of 1927. At that time, when the Northern Expeditionary Army arrived in Wuhan, some comrades became proud and thought they were so proud that they forgot that the Kuomintang was going to attack us. As a result, he made mistakes in Chen Duxiu’s line, which led to the failure of this revolution. The second time was in 1930. The Red Army took advantage of the conditions of Jiang Fengyan’s war to win some battles, and some comrades became proud and self-righteous. As a result, he made mistakes in Li Lisan’s line and suffered some losses to the revolutionary forces. The third time was in 1931. The Red Army broke the third "encirclement and suppression" campaign, and then the people of the whole country launched a vigorous anti-Japanese movement in the face of the Japanese attack, and some comrades became proud and thought they were great. As a result, we made more serious mistakes in the line, and lost about 90% of the revolutionary forces that we worked hard to gather. The fourth time was in 1938. With the anti-Japanese war, the United front has been established, and some comrades have become proud and self-righteous.As a result, I made some mistakes similar to the Chen Duxiu route. This time, the revolutionary work in those places most affected by these comrades’ wrong ideas has suffered great losses. For this reason, he demanded in his speech: "All Party comrades should take these pride and mistakes as a warning", let go of the "burden" of "arrogance" and "don’t repeat the mistakes of pride when winning". Previously, Guo Moruo’s "Three Hundred Years Festival of Jiashen" was issued as a rectification document for the whole party to study. On November 21, 1944, in a letter to Guo Moruo, Mao Zedong wrote: "A small victory is pride, and a big victory is more proud. It is worth noting how to avoid this kind of problem." He himself is even more"Be conscientious, for fear that something will go wrong, but maybe something will come out from somewhere.", request"What mistakes have you seen? I hope to know at any time."

Judging from the actual situation of the party, although the party and its leading team have developed as never before, the China revolution has not yet won. We have more than 900,000 troops, but they are not centralized, but divided and can only fight the sparrow war. Our base area has a population of more than 90 million, but it is not a whole, but it is also divided; Our enemies are still very strong, including the powerful Japanese imperialism and the Kuomintang. Although these two enemies are not the same type, they are "one guarding our front door and the other guarding our back door". Compared with the enemy, our strength is very small, and there are still difficulties ahead. Our situation is still very harsh. All these also require us to.We should not only "strive bravely" but also "be modest and prudent", and we should not repeat the historical saying that when we were young, we were comfortable and had nothing to do, but when we were big, our brains swelled up, our heads swelled up, we became proud and our hearts became impatient.The mistake.

　　After talking about 17 difficulties, Mao Zedong then talked about the "bright side" of eight aspects to ensure that "we must win", including:First, "temporary loss, final victory"; Second, "if you fail here, you will win there", "If the east is not bright, the west will be bright, and if it is dark, the south will have the north"; Third, "some people ran away and some people came"; Fourth, "some people are dead and some people are alive"; Fifth, "learn to do economic work when you are in economic difficulties" and "do it yourself and develop production"; Sixth, "to overcome natural disasters, Taihang has experience, and communist party will catch locusts"; Seventh, "disputes within the party give us exercise, and a big dispute is a big exercise"; Eighth, "learn to be self-reliant without international assistance", and so on.

On the basis of estimating both "difficulties" and "light", the Seventh National Congress of the Communist Party of China formulated a set of correct lines, programs and strategies around the party’s central task, which laid a solid political, ideological and organizational foundation for the party’s leadership to win the victory of War of Resistance against Japanese Aggression and the victory of the new-democratic revolution throughout the country.

"Now that we have won the world, we still have to imagine from the worst possibility."

Preparing for the worst, in the final analysis, is to get the best future and results.

Shortly after the victory of the Anti-Japanese War, some of the "seventeen difficulties" envisioned by Mao Zedong at the Seventh National Congress really met, some of them happened, and even some "other unexpected things" appeared. For example, less than two years after the closing of the Seventh National Congress, Yan ‘an, the seat of the Central Committee, was occupied by Kuomintang troops, which was unexpected when the Seventh National Congress was held. However, it is precisely because of our mental preparation to deal with all difficulties that we voluntarily abandoned Yan ‘an and regained Yan ‘an. Mao Zedong’s original idea of "fighting for five years or so to fundamentally overthrow the Kuomintang" was finally achieved in only three years.

In Mao Zedong’s view, everything should be prepared from the most difficult and the worst, and strive for the best result. Such a thinking method, working method and leadership method should always be adhered to, whether in the revolutionary war era or in the period of peaceful construction. On January 27th, 1957, in his speech at the meeting of party secretaries of provinces, municipalities and autonomous regions, Mao Zedong said: "I think we should prepare for something big. If you are prepared for something big, it may not happen. If you are not prepared for something big, trouble will come out. The development of things is nothing more than two possibilities: good and bad. We must estimate two possibilities for both international and domestic problems. You said it would be peaceful this year, maybe it would be peaceful. However, it is not good for you to put your work on the basis of this estimate, and you should imagine it on the worst basis. Internationally, it is nothing more than fighting a world war and throwing atomic bombs. At home, there was nothing more than a national chaos, the "Hungarian incident", and millions of people rose up against us, occupied hundreds of counties, and fought in Beijing. We will only go to Yan ‘an again, and that’s where we came from. We have lived in Beijing for seven years, and what if we are invited back to Yan ‘an in the eighth year? Everyone is crying, crying? …..’ seven’, I said to estimate to seventeen difficulties, including bare land thousands of miles, famine, no food, all the county lost. We have made such a full estimate, so we are always in the initiative. Now that we have won the world, we still have to imagine from the worst possible. "

In his speech at the Central Working Conference in Chengdu on March 25th, 1958, Mao Zedong proposed to prepare for the unexpected. He said: We didn’t expect the international criticism of Stalin and the Polish-Hungarian incident in 1956, and there were some things that we didn’t expect at home. What is unexpected in the future? What may be unexpected at home and abroad? For example, if there is a world war, the madman wants to fight, and the atomic bomb will smash all of us, there is no way. What problems will happen in the Soviet Union? He once again talked about the "seventeen difficulties" mentioned in the past, saying: I remember that at the Seventh National Congress, seventeen were listed, among which "a thousand miles away in bare land" was a drought; There is also a loss of all county towns, and we only have villages. He asked the party groups of all provinces and ministries to talk about unexpected dangers that may occur at home and abroad and make a list, not 17, but 16. He said: If we are not prepared, when that thing comes, we will be worse. For example, a few leaders in Xizang may defect, and the hearts of the upper class are perfunctory to us in India, Britain and the United States, so we can make a list.

Unfortunately, with the gradual "Left" deviation of the Party’s guiding ideology for socialist construction, we have seriously underestimated the long-term, arduous and complex nature of China’s socialist construction and underestimated the "worst possible". We have become proud and underestimated our enemy. In the course of hard exploration of the road to socialist construction, we have made mistakes again, suffered big losses and left a serious lesson. This is what we still need to reflect on and "take a warning" today.

Everything is established in advance, and it is abolished if it is not foreseen.Mao Zedong’s thinking method of "establishing our policy in the worst possible way" and the "seventeen difficulties" listed provide us with an example of persisting in and making good use of the bottom line thinking to seek business.At present, China’s economic and social development is in a critical period of "three-phase superposition", and the task of comprehensively deepening reform is arduous. On the journey of thoroughly implementing the "four comprehensive" strategic layout and solidly advancing the goal of "two hundred years", we should keep a clear head, start with the worst in everything, imagine all kinds of possibilities, "make it happen before it happens", make a good "first move", play a good initiative and properly solve all kinds of predictable and unpredictable problems in our career development."The reason why our cause is great is that we have experienced difficulties that are rare in the world and have continued to succeed."All difficulties can’t stop the people of China from striding forward. Seventy-one years ago, when Mao Zedong expounded the future of China at the Seventh National Congress, he said a passage, which I think is still applicable at the end of this article:"We clearly understand that in front of us and the people of China, there are still great difficulties, many obstacles and many detours. However, we also know that we, together with the people of the whole country, will be able to overcome any difficulties and obstacles, so that China’s historical task can be completed. "

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　　According to the relevant provisions of the "Regulations on the Openness of Government Information in People’s Republic of China (PRC)", the China Securities Regulatory Commission 201 is hereby promulgated.eightAnnual report on government information disclosure in. The contents of this report include voluntary disclosure of information, disclosure of information according to application, construction of information disclosure mechanism platform, information disclosure fees and reductions, application for administrative reconsideration and administrative litigation due to information disclosure, existing problems and improvement measures.

　　I. Active disclosure of information

　　201eightIn, China Securities Regulatory Commission and its dispatched offices made public government information through websites and other forms.14656strip,Which will be open to the public.5203strip,All agencies are open to the public.9453Article (For details of the information disclosure of the dispatched offices, please refer to the Unit 201 issued by the securities regulatory bureaus.eightAnnual report on government information disclosure). The government information voluntarily disclosed by the government organs mainly covers the following aspects:

　　(a) important regulatory policies and measures and dynamic information.

　　Publish major regulatory news in the column of "Highlights of CSRC"322Article. It mainly includes the important work meetings, important regulatory policies, listing of new products, investigation and handling of market violations, international regulatory cooperation and the progress of key work. Publish the order of the CSRC in the columns of "Order of the CSRC" and "Announcement of the CSRC"15Item, CSRC announcement40Item. The implementation of the "Notice of the General Office of the State Council on Doing a Good Job in the Disclosure of the Results of the Proposals of NPC Deputies and Committee Members Chinese People’s Political Consultative Conference" was made public.53A reply to the proposal of NPC deputies and the proposal of Committee member Chinese People’s Political Consultative Conference that I will handle.

　　(2) Administrative examination and approval information

　　Make a list of administrative examination and approval intermediary services and publish it on our website, including the name of the items, the basis for setting, the implementing agencies, fees and other information, so as to facilitate social supervision. Revise the service guide for administrative licensing matters.

　　In the audit of the company’s public offering of shares, the prospectus of the public initial public offering of shares (pre-disclosure and supplementary pre-disclosure)468The announcement of the meeting and the announcement of the audit results.33841 pieces of feedback on refinancing, 25 pieces of audit opinions of the audit committee, 6 pieces of questions and answers on issuance supervision, and 4 pieces of information disclosure quality spot check and lottery of the first-time enterprise. In the audit of unlisted public companies, there were 56 prospectus (declaration draft), 30 feedback opinions on applying for issuing shares to specific objects, 35 responses to feedback opinions on applying for issuing shares to specific objects, and 54 audit opinions on applying for issuing shares to specific objects. In the review of mergers and acquisitions of listed companies, there were 156 announcements of public mergers and acquisitions Committee meetings and audit results, and 169 feedback opinions on mergers and acquisitions. In the audit of corporate bond issuance, the prospectus of corporate bond offering (pre-disclosure) is made public.threeParts, feedbacktwentyPieces. Update and release the progress of initial public offering, merger and reorganization of listed companies, raising of securities investment funds, acceptance and review of administrative licensing matters such as securities and fund management institutions every week.

　　(three) inspection, punishment and administrative reconsideration information

　　Publish all kinds of inspection and law enforcement information in the column of "Inspection Bureau"24Article and case10Pieces. In the "Administrative Punishment Committee" column, the administrative punishment decision was issued.130A, market ban decision19Pieces. Publish the administrative reconsideration decision in the column of "Administrative Reconsideration"95Pieces.

　　(4) Market statistical information

　　Publish "Securities Market Express" in the column of "Statistical Data"110,Industry Classification of Listed Companies, 4 issues, Futures Market Weekly, 52 issues and Futures Market Monthly, 12 issues.

　　(5) Directory of legal institutions and information on regulatory cooperation.

　　existSecurities Regulatory Commission official websiteUpdate and release the list of securities companies, futures companies, public offering securities investment funds, Public Offering of Fund management institutions, subsidiaries of fund management companies engaged in asset management business of specific customers, custodians of securities investment funds, sales, payment and settlement institutions of publicly raised funds, custodians of qualified foreign institutional investors, qualified foreign institutional investors in RMB, qualified foreign institutional investors and securities investment consulting institutions.wait for.

　　(6) Annual Report of the CSRC

　　In the column of "Understanding CSRC", I will publish 201.sevenThe annual report of 2008 systematically introduces the supervisory responsibilities and structure of our association, as well as its work in regulatory reform, system construction, innovation and development, risk prevention, legal system construction, inspection and law enforcement, investor protection, opening up and international cooperation.

　　(7) Department budget and final accounts

　　201eightApril 200813Day, announced that I will 201.eightAnnual departmental budget. 201eightJuly 2, 20080Day, announced that I will 201.sevenAnnual departmental accounts. The public content is refined to the item-level subjects of expenditure function classification. According to the requirements of the Ministry of Finance, the "three public funds" have disclosed the budget of all financial allocations, as well as the purchase and possession of official vehicles, the domestic official reception situation, the reasons for the increase or decrease of the "three public funds" and other information, and detailed the delegations and numbers going abroad on business.

　　II. Information disclosure upon application

　　In 2018, I will receive a total of 1227 applications for government information disclosure. Among them, 93 were on-site applications, accounting for 7.58%; 537 online applications, accounting for 43.77%; There were 596 letter applications, accounting for 48.57%.

　　Responded to 1199 applications for government information disclosure. Among them, 427 pieces have been voluntarily disclosed, accounting for 35.61%; 98 cases agreed to answer publicly, accounting for 8.17%; 196 did not agree with the public reply, accounting for 16.35%; 181 cases not disclosed by this administrative organ, accounting for 15.10%; There were 218 cases where the application information did not exist, accounting for 18.18%.　　

　　Iii. Construction of information disclosure mechanism platform

　　Adhere to and improve the routine press conference system. 201eightIn, held throughout the year 4.eightA routine press conference, take the initiative to release news.322Article, responding to the number of hot spots or major public opinions of public concern76A.

　　On the one hand, continue to do a good job in official website construction and daily operation and maintenance, and adjust and set up new website columns.214Item. On the other hand, efforts were made to build a "two micro-ends" comprehensive publicity platform, successfully launched the official mobile phone client of the CSRC, and enhanced the information disclosure ability and influence. As of 201eightDecember 31, 2008, Weibo fans of CSRC.579Ten thousand, the number of WeChat subscriptionsseventy-twoTen thousand, 48 regular press conferences were released through Weibo WeChat, and Weibo was released.790Article, wechat431strip.

　　Four, information disclosure fees and exemptions

　　201eightIn 2008, we did not charge any fees for searching, copying and mailing related to the disclosure of regulatory information.

　　V. Application for administrative reconsideration and administrative litigation due to information disclosure

　　In 2018, I received a total of eight applications for administrative reconsideration involving the disclosure of government information by government agencies, one of which partially revoked the specific administrative act, and the rest decided to maintain the specific administrative act. There were 7 new administrative litigation cases of information disclosure with our agency as the defendant, and 6 cases were carried forward from previous years. Among them, 6 cases were upheld by specific administrative actions or judgments to reject the plaintiff’s claims, and the other 7 cases are still in the process of court hearing.

　　VI. Existing Problems and Improvement Measures

　　The ways and scope of voluntary disclosure of government information need to continue to meet the market demand, and the level of disclosure of regulatory information according to application needs to be further improved. 201nineIn, I will continue to follow the Opinions of the General Offices of the General Office of the Central Committee of the CPC and the State Council on Comprehensively Promoting the Openness of Government Affairs (No.8 [2016] of the Central Office) and the General Office of the State Council on Printing and Distributing.<关于全面推进政务公开工作的意见>Notice of the Implementation Rules (Guo Ban Fa [2016] No.80) promotes the information disclosure of the securities and futures regulatory system, strengthens policy interpretation, enhances the effectiveness of publicity, and promotes the healthy development of the capital market.

　　2016年1月12日，中共中央总书记、国家主席、中央军委主席最高领袖在中国共产党第十八届中央纪律检查委员会第六次全体会议上发表重要讲话。资料图

　　中国青年网北京5月22日电（记者开可）2012年，十八届中共中央政治局常委同中外记者见面会上，以最高领袖为总书记的新一届党中央向全国人民发出了从严治党的承诺。如今，从严治党已经成为常态，深入人心，赢得民心。从严治党对基层的青年党员来说，不仅是一场永没有休止符的考验，更是他们上进的动力。从严治党，让青年党员们有了干劲。

　　明规则替换潜规则青年党员点赞

　　2014年5月，最高领袖在河南省兰考县指导兰考县委常委班子专题民主生活会并发表重要讲话。在讲话中，最高领袖明确提出了用明规则替换潜规则。

　　“立明规则，破潜规则，必须在党内形成弘扬正气的大气候。大气候不形成，小气候自然就会成气候。”“破除潜规则，根本之策是强化明规则，以正压邪，让潜规则在党内以及社会上失去土壤、失去通道、失去市场。全党上下，任何一级组织、任何一名党员和干部都要严格遵守党的组织制度和党的法规纪律，对党忠诚，光明磊落，公道正派。”

　　用明规则替换潜规则，在国网山东省电力公司工作黄传锋首先想到的就是入党的“由易变难”。在国网山东省电力公司工作的黄传锋是一名有着二十多年党龄的老党员。据他告诉记者介绍，以前入党的时候就是写一份入党申请书，表现好一点就可以了，或者是工作时间年限够了，应该入党了，就写一份申请书上交。但是现在变得“有点困难”。入党考虑地更加全面，要从入党积极分子的各方面进行综合考虑，用黄传锋的话说就是：“得脚踏实地好好干才能有（入党）机会。”

　　“做事都按照规则去做，不搞潜规则。官僚主义作风、不民主、不公正，消灭这些潜规则才能让党的发展更加规范，才更能让人看到希望。”天津大学生村官杨代显说，用明规则替换潜规则，对青年党员、有上进心的党员是非常大的鼓舞。

　　相比黄传锋，天津大学生村官杨代显的党龄虽然只有六年，但是觉悟一点都不差。“我们青年党员非常支持和赞同习总书记提出的从严治党。这也让我们看到了希望。我们从中获得了一种力量，就是咱们的党始终处于先进地位。可是我们年轻的党员也要反思：对于党章的每一条都遵守了吗？是一名合格的党员吗？”杨代显觉得，从严治党是对每一名党员的考验。

　　In Yang Daixian’s view, party member must have its own principles and abide by party constitution. In the interview, Yang Daixian spoke the voice of many young party member: "As a young party member, we hate corruption and violate party discipline and rules." "We are to serve the people. If we all have problems ourselves, how can we serve the people and how can the people recognize us? " Yang Daixian said.

　　The new situation of strictly administering the partyYoung party member has drive.

　　"At that time, joining the party had to take part in the study, learn the little red book of party constitution, and then take the exam." Yang Daixian said that what impressed him the most was the scene of studying communist party and party constitution during the entrance examination.

　　"The introducer briefly introduces the situation and explains the nature of our party and what kind of promotion (joining the party) has for individuals." Yang Daixian told reporters that he sometimes wondered why he felt close to the party organization at the beginning. "The party represents the advanced and pursuit. At that time, I felt it was a special honor to join the party, and it was also to better serve my classmates. Moreover, seeing the deeds of old party member is very touching, it has strengthened the belief of joining communist party. "

　　从严治党为每一名党员提出了要求、敲响了警钟。“我们青年党员对习总书记提出的从严治党非常支持和赞同。”杨代显告诉记者，“这样才能使党永葆青春，使党永远保持先进性。老百姓才能真正拥护党。”

　　长期在基层工作，每天都和老百姓打交道，杨代显对“群众的眼睛是雪亮的”这句话深有感触。“群众的眼睛是雪亮的，如果咱们有问题，肯定不会支持我们。有很多事他们不直接参与并不代表不关心。”杨代显给记者举例说：“选举党支部书记是党内的问题，都是党员来选。但是咱们的村民肯定都会讨论。谁当了书记能为咱们大家做好事，谁不行。然后就会和我们沟通、推荐。老百姓心里是有一杆秤的。”为民办事，自身清廉，老百姓才能真正地支持和拥护。

　　对于黄传锋来说，老百姓的拥护是来自于真的为人民办事。“学习党章，为人民服务，真正落实到行动上来。”黄传锋告诉记者，以前老百姓办事“脸难看，门难进”的情况已经减少了很多。他以自己的工作单位举例说：“像我们供电部门只要一个电话，我们的服务就能全部到位，主动上门。比如企业投资需要安装变压器，只需要给我们供电所打一个电话，我们了解情况后会在几个工作日之内将变压器安装好。”

　　Huang Chuanfeng described the strict administration of the party as a spring breeze blowing at the grassroots level. There is an upsurge of "two studies and one work" between party member at the grass-roots level. "The company’s project department set up a temporary party group, and everyone often studied the party’s documents and spirit together. In the first hour of working hours in the first week of each month, (the group) learns the party class first and then the safety regulations. Now it’s changed to &lsquo; Two studies and one doing &rsquo; . The masses generally reflect that our work is solid. " Huang Chuanfeng said.

　　"Strictly administering the party has won the hearts of the people for the party. Re-study party constitution, take party classes, and look up to the old comrades and model party member. Models can play a leading role, and we just have to follow them unswervingly, not lagging behind in thought, and not lagging behind in action. " Huang Chuanfeng said that they have established a "mentoring" model, with model party member driving excellent party member, excellent party member driving ordinary party member, and then ordinary party member driving new party member. Driven by layers, not only qualified party member is cultivated, but also the enthusiasm of party member to serve the people.

1905 movie network news Directed by Liu Qian and Wu Zhi, the film starring, starring and starring, starring and co-starring is being warmly shown all over the country. After three days of release, the box office has exceeded 90 million, with a Taobao Film score of 9.5 and a cat’s eye score of 9.4, which has won great recognition from the audience. The newly released "Warm Winter" word-of-mouth feature shows the emotional strength of warmth and healing in Goodbye, Li Cola, and the beautiful writing of love and courage, which shines into the hearts of every audience like sunshine, adding a touch of family color to this cold winter.

Family microcosm reflects real life, understanding and tolerance bring hope and new life

"Goodbye, Li Kele" turns warmth into the background color, and interprets "love and parting" with heart. This is a journey to repair the cracks of a broken family, and it is also a healing journey for Li Yan (Seven) and Pan Yanqiu (NI YAN) to reconcile with each other and themselves. After watching the movie, many viewers shouted "I didn’t expect to cry so much", "It’s too substitutive" and "There are too many places where life resonates".

In the film, extubation for father Li Boyu (Jason Wu) is a thorn in the heart of mother and daughter, and it is also a taboo that this family can’t touch. I can’t accept the departure of my closest relatives, and my thoughts and reluctance turn into remorse and obsession. The increasingly fierce contradiction between mother and daughter is the epitome of many "Chinese families". Countless viewers have seen the way they used to get along with their parents, and this movie made them realize that "many people are too late to say goodbye", as Jason Wu said, "I am most afraid of losing the people I care about most when I least expect them". Only cherish the present, understand each other and tolerate each other can we not regret.

It is also a particularly moving point in Goodbye, Li Kele to show "the tolerance of father’s love and the forbearance of mother’s love" from the perspective of Meng Chong’s "Coke". When my father’s love turned into the companionship of coke, which tore the gap between mother and daughter, many young viewers choked up, saying that they had ignored the consistent background color under their parents’ tough appearance like Sinan (Seven), that is, the deep love as "a thousand dollars". Life may be stranded, but love is always vast. Whether it is the departure of relatives or the irreconcilable self, there are always some opportunities &mdash; &mdash; It can be a puppy, a "golden daughter" dowry, or even a movie &mdash; &mdash; Can let us find the lost beauty, turn the pain into the power to guide forward, let us bravely say "goodbye" to the past and "hello" to the future.

The cute dog "Coke" pokes the heart and performs the cute audience. Lao Li’s family of four laughs and tears to heal the pain.

The excellent performance of the cute dog "Coke" is a big selling point of "Goodbye, Li Coke", which captured the hearts of all the audience. In particular, the dog who played the "Coke" for the elderly was the "God Dog Seven" who once accompanied us in our youth. Now, returning to the big screen, it is not only the embodiment of father’s love, but also an important family member of the "Lao Li family", which accompanied the family through ups and downs and gained the love of many audiences. The bridge of "Coke" saving the puppy’s partner left a deep impression on many viewers and brought a relaxed and happy atmosphere for watching movies. The scene where NI YAN beat up the dog thief also made many viewers clap their hands and shout "It’s so cool". In the movie, "coke" is family, in real life, the dog is our friend; The company of "Coke" cured the injured "Lao Li family". In reality, the puppy is also healing us and our world.

"Goodbye, Li Kele" presents a miniature of a family to the audience from such a unique pet perspective, arousing strong resonance and bringing laughter to everyone at the same time. With warmth and companionship, it guides us to heal the pain and find the courage to move forward. "What is brave? Don’t look back." I believe everyone can see themselves from the film clips, the corner of the family, the sea of life and the true meaning of love to us.

The movie "Goodbye, Li Kele" is in a warm and enthusiastic nationwide.

Special topic: picture channel

　　

The sheep was eaten by the tiger, and Sun was really distressed. Peng Dan/photo

　　On January 19th, a wild Siberian tiger reappeared in Hunchun, staying for 11 hours in a sheepfold near Wushe Village, Taiyang Village, Banshi Town, without any fear of gunfire. As a result, 22 sheep were killed.

　　Near the ruins of Shitouhe Ancient City, Wushe, Taiyang Village, Banshi Town, there is a sheepfold containing more than 300 sheep. The owners of these sheep are Sun Mou, a professional sheep farmer. According to Sun, at 17 o’clock on January 19, he was resting in the house when he suddenly heard an abnormal noise in the sheepfold more than 10 meters away from the house, so he quickly ran out to see what had happened. It doesn’t matter at first sight. I saw an extra tiger in the sheepfold, biting a sheep’s hip. Sun was so scared that his legs were weak. After a while, he calmed down and immediately ran back to the house to call the police.

　　When the police of Hunchun Forest Public Security Bureau rushed to the scene of the incident, there was already a river of blood in the sheepfold. Through the lighting facilities, people at the scene saw that it was a male Siberian tiger weighing more than 200 kilograms. The policeman sat in the car and tried to scare the tiger away by firing a gun. However, the tiger didn’t seem to be afraid. He still ate delicious food with relish until his stomach became bulging, and then he swaggered away. At this time, it was already 4 am the next day. After confirming that the tiger left, the police came to the sheepfold to check. A total of 22 sheep were buried in the tiger’s mouth, of which two were all eaten and 20 sheep were bitten off.

　　According to the staff of Hunchun Forestry Bureau, the place where the Northeast Tiger committed the crime was only 10 kilometers away from the urban area, 5 kilometers away from the Hunchun Quanhe Port and 1 kilometer away from the nearby villages, belonging to the border between China and Russia. The staff of the bureau have surveyed the site and the relevant compensation matters are in progress. Reporter Peng Dan/Report

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