Notice of Guangzhou Haizhu District Housing and Construction Bureau on Printing and Distributing the Work Guidelines for the Open Introduction of Cooperative Enterprises and Cooperative Intention Ente

Notice of Guangzhou Haizhu District Housing and Construction Bureau on Printing and Distributing the Work Guidelines for Introducing Cooperative Enterprises and Enterprises with Intention in Guangzhou Haizhu District Old Village Renovation Project [2021] No.1 Notice of Guangzhou Haizhu District Housing and Construction Bureau on Printing and Distributing the Work Guidelines for Introducing Cooperative Enterprises and Enterprises with Intention in Guangzhou Haizhu District Old Village Renovation Project: The Work Guidelines for Introducing Cooperative Enterprises and Enterprises with Intention in Guangzhou Haizhu District Old Village Renovation Project have been approved by Haizhu District People’s Government and are hereby issued to you. Problems encountered in the implementation, please report to Haizhu District Housing and Construction Bureau. Guangzhou Haizhu District Housing and Construction Bureau April 2, 2021 Guangzhou Haizhu District Old Village Renovation Project Work Guidelines for Open Introduction of Cooperative Enterprises and Cooperative Intention Enterprises According to the work deployment of deepening urban renewal and promoting high-quality development at the 11th Plenary Session of the 11th Municipal Party Committee, in order to accelerate the implementation of Haizhu District’s old village renovation project listed in the "three-year plan, five-year plan and ten-year plan", Further standardize the behavior of openly introducing cooperative enterprises and cooperative enterprises in the process of old village reconstruction, realize the principles of openness, fairness, impartiality and merit-based, and select powerful enterprises to participate in old village reconstruction. According to the Regulations on the Management of Rural Collective Economic Organizations in Guangdong Province (Order No.189 of Guangdong Provincial People’s Government), Guangzhou Urban Renewal Measures (Order No.134 of Guangzhou Municipal People’s Government) and the General Office of Guangzhou Municipal People’s Government on Printing and Distributing Supporting Documents of Guangzhou Urban Renewal Measures,(Sui Fu Ban [2015] No.56), Implementation Opinions of Guangzhou Municipal People’s Government on Improving Urban Renewal Level and Promoting Economical and Intensive Land Use (Sui Fu Gui [2017] No.6), Notice of the General Office of Guangzhou Municipal People’s Government on Printing and Distributing the Implementation Rules for Further Promoting Urban Renewal in Guangzhou (Sui Fu Ban Gui [2019] No.5), These work guidelines are formulated in accordance with the Notice of Guangzhou Housing and Urban-Rural Development Bureau on Printing and Distributing the Opinions on Further Standardizing the Relevant Matters Concerning the Selection of Cooperative Enterprises for Cooperative Renovation Projects in Old Villages (Sui Jian Gui Zi [2020] No.16) and the Notice of Guangzhou Housing and Urban-Rural Development Bureau on Printing and Distributing the Guidelines for the Introduction and Exit of Cooperative Enterprises in Urban Village Renovation in Guangzhou (Sui Jian Gui Zi [2021] No.1). I. General Requirements (1) Guiding ideology Guided by Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era, we will resolutely implement the work arrangements of the plenary session of the municipal party committee and district committee to deepen urban renewal and promote high-quality development, adhere to the leadership of the party, adhere to the guidance of party building, and strengthen the leadership, organization, overall planning and supervision role of grassroots party organizations in standardizing the work of openly introducing cooperative enterprises and cooperative enterprises in the renovation and reconstruction projects of old villages in our district, so as to ensure the smooth progress of the renovation of old villages. (II) Basic Principles 1. The principle of fully respecting villagers’ wishes and decision-making power. 2. The principles of openness, fairness, justice, honesty and credibility.3. The principle of comprehensive consideration and selection based on factors such as development ability, financial strength, performance experience, industrial introduction, urban service and tax contribution to the local area. 4. The basic data survey of old village reconstruction is organized by the government, and a certain number of members’ representatives are invited to participate. Old villages that introduce cooperative intention enterprises should stipulate in the cooperative intention agreement that cooperative intention enterprises shall not conduct basic data surveys on their own. 5. After the district government publishes the basic data, the village collective economic organizations can introduce cooperative enterprises. (III) Scope of Application These work guidelines apply to cooperative enterprises or cooperative enterprises that are openly introduced into cooperative transformation projects of old villages within their respective administrative areas. Choose to transform the old village independently, and the village collective economic organization shall not transfer the equity in principle; The transfer of equity shall be regarded as cooperative transformation and shall be implemented in accordance with the relevant provisions of these work guidelines. In addition to the cooperative transformation projects of old villages that have been approved and substantially promoted before the issuance of the Notice on Printing and Distributing the Relevant Procedures for Further Standardizing the Reconstruction of Villages in Cities (Sui Jiu Gai Ban [2011] No.51), cooperative enterprises have been selected according to Article 25 of the Implementation Measures for the Renewal of Old Villages in Guangzhou (Order No.134 of Guangzhou Municipal People’s Government) before January 19, 2018. And before the issuance of this guideline, it has been in accordance with the Notice of Guangzhou Urban Renewal Bureau on Printing and Distributing the Opinions on Further Standardizing the Relevant Matters Concerning the Selection of Cooperative Enterprises for Cooperative Renovation Projects in Old Villages (Sui Xin Gui Zi [2018] No.1).Or "Notice of Guangzhou Housing and Urban-Rural Development Bureau on Printing and Distributing Opinions on Further Standardizing the Relevant Matters Concerning the Selection of Cooperative Enterprises for Cooperative Renovation Projects in Old Villages" (Sui Jian Gui Zi [2020] No.16), where cooperative enterprises or cooperative enterprises are introduced and are still within the validity period of the agreement, cooperative transformation of old villages within their respective administrative areas shall be openly introduced according to the requirements of these work guidelines. (IV) Introducing Path Village Collective Economic Organizations Before introducing cooperative enterprises, they may introduce cooperative enterprises as needed. Introduce cooperative enterprises and cooperative enterprises in accordance with the procedures stipulated in these guidelines. Ii. conditions for introduction and contents of attracting investment (I) the qualifications and requirements of cooperative enterprises and cooperative enterprises are as follows: 1. the paid-in registered capital is not less than 500 million yuan (subject to the capital verification report). 2. Have the second-class qualification and above real estate development qualification, and have the development ability matching the transformed plots. Engaged in real estate development and operation for more than 3 years; There are not less than 20 professional managers with professional titles in construction, structure, finance, real estate and related economy, including not less than 10 managers with intermediate or above titles and not less than 3 full-time accountants with qualification certificates; The person in charge of engineering technology, finance, statistics and other businesses has the corresponding professional intermediate title or above. 3 in the past three years, the housing construction area has been completed more than 150,000 square meters;In Beijing, Shanghai, Guangzhou, Shenzhen and other first-tier cities in the country, at least one urban renewal and comprehensive transformation project has been completed or is being promoted. 4. Financial strength: the total assets of the enterprise shall not be less than 20 billion yuan for projects with the current construction area less than 600,000 square meters within the scope of transformation; The total assets of an enterprise with a current construction area of 600,000 square meters or more shall not be less than 30 billion yuan. The net assets of the enterprise shall not be less than 5 billion yuan. 5. It has the industrial layout and the ability to introduce industries that match the transformed plots, and conforms to the provisions of Article 8 of the Guidelines for the Introduction and Exit of Cooperative Enterprises in the Reconstruction of Villages in Guangzhou (Sui Jian Gui Zi [2021] No.1). 6. The enterprise has a good credit reputation, a strong sense of social responsibility, and a good bank credit record. It has been inquired by the national enterprise credit information publicity system, credit China (Guangdong, Guangzhou), the People’s Bank Credit Information Center and other departments in the past five years, and there are no serious violations of laws and regulations and records of not stressing integrity in the departments of financial supervision, market supervision, taxation, construction and planning of land, urban management, education, culture, tourism, health and health, and there is no "unfinished" or engineering. By inquiring the records of Guangzhou Public Resource Trading Center, there is no case of suspension or cancellation of bidding qualification according to law. 7. In the real estate and other projects developed by an enterprise in Haizhu District, if there are any supporting facilities that have not been handed over to the public and do not cooperate with land acquisition and demolition, it is deemed that there is a problem with the integrity and credibility of the enterprise, which does not meet the relevant provisions of point 6 above. 8. The enterprise is a company established in Haizhu District to undertake the renovation project of the old village, and its controlling shareholder.(The shareholding ratio must be ≧51%) If the enterprise meets the qualifications and conditions specified in points 2-7 above, and promises to take joint responsibility for the old village renovation project, it is deemed that the enterprise meets the corresponding qualifications and conditions. 9. In principle, the number of members of an enterprise consortium shall not exceed 3, and the main enterprise with the above qualifications shall occupy no less than 51% of the consortium. Other requirements for the membership of the remaining consortium may be set according to the actual needs of the project. 10. For enterprises with outstanding industrial layout or industrial introduction ability (non-real estate industry), but without corresponding real estate qualifications, development ability and experience, they can form a consortium with enterprises with the above-mentioned fifth real estate development ability and experience to participate in the bidding for the transformation of old villages. 11. The enterprise shall, within 30 natural days from the date of signing the cooperation intention agreement or cooperation agreement, pay the performance bond of the cooperation intention agreement or the campaign deposit of the cooperative enterprise according to the following standards: (1) For the project with a land area of less than 30 hectares, it shall pay a performance bond or deposit of not less than 200 million yuan (cash); (2) For projects with a land area of more than (equal to) 30 hectares, a performance bond or deposit of not less than 300 million yuan (cash) shall be paid. 12. The introduced cooperative enterprise shall stipulate in the signed cooperation agreement that within one month from the date of signing the cooperation agreement, a project company with independent legal personality shall be established in Haizhu District, and industrial and commercial registration, tax registration and other formalities shall be handled; Without the consent of the village collective economic organizations, the project company shall not change its shareholders or transfer its equity. Otherwise,The contractual joint venture shall be liable for breach of contract. Before voting, the village collective economic organizations should study through the village collective party committee and report to the District Housing and Construction Bureau for guidance, and then make a collective vote. If the situation is complicated, the district housing and construction bureau will report to the leading group for urban renewal in the district. Enterprises (or private non-enterprise units) introduced through cooperative enterprises shall set up (or move in from outside) project companies (or other operating entities and private non-enterprise units, excluding relocated enterprises in the area and real estate enterprises) in Haizhu District within the agreed time. 13. The introduced cooperative enterprise shall undertake the construction of public welfare projects in the surrounding areas of the project, and allocate schools, hospitals and supporting facilities in accordance with the requirements of Articles 12 and 13 of the Guidelines for the Introduction and Exit of Cooperative Enterprises in the Reconstruction of Villages in Guangzhou (Sui Jian Gui Zi [2021] No.1), so as to improve the overall efficiency of the old village reconstruction. 14 other conditions that need to be set according to the actual situation of the old village renovation project. 15. If the city newly introduces the necessary conditions in the relevant documents for the introduction of cooperative enterprises in the future, this part should be added. If there is any conflict between these guidelines and the new policies of the city in the future, they shall be implemented according to the standards not lower than those of the new policies of the city. (II) Contents of Investment Promotion The investment promotion document shall include the following contents: 1. Basic information of the transformation object and the basic data results of the old village audited and published by the district government. 2. Introduce the qualification requirements of the cooperative enterprise. 3. The idea and preliminary plan of project renewal and transformation compiled by the applicant cooperative enterprise according to the basic data published by the government.4. Requirements for the cooperative enterprise to introduce resources such as industry, education and medical care. A cooperative enterprise shall sign a supervision agreement and a letter of commitment according to the requirements of the District Investment Promotion Bureau, clarify the contents and requirements of industrial introduction, and clarify the construction and operation requirements of public facilities such as education and medical care, so as to ensure substantial progress in project construction within three years and substantial results in industrial introduction after project construction; The performance of the contract is included in the integrity management. 5. The methods and procedures for openly introducing the cooperative enterprise (including the composition of the qualification review team, etc.). 6. Substantive contents such as cooperation agreement and requirements for the amount of deposit. 7. Evaluation methods and standards. 8. Other contents that should be included. Third, the introduction of cooperative intention enterprise process (a) announcement and qualification review 1. The proposal of the village collective party Committee whether to introduce cooperative intention enterprises, after being studied and approved by the village collective "two committees", will be voted by the members’ congress. 2. Within 20 natural days after the vote is passed, the village collective economic organization shall prepare and complete the announcement on the open introduction of cooperative enterprises, and submit it to the local streets, which shall solicit the opinions of the District Housing and Construction Bureau. 3. The village collective economic organizations publish the announcement information of openly introducing cooperative enterprises within the village scope, and accept the registration. The announcement time is 5 working days, and the registration time is 3 natural days. 4. On the basis of soliciting villagers’ opinions and according to the model provided by the District Housing and Construction Bureau, the village collective economic organization drafts the cooperation intention agreement, which is submitted to the local street for review after being studied and agreed by the village collective party committee.The territorial street shall solicit the opinions of the District Housing and Construction Bureau in writing, and the District Housing and Construction Bureau shall give a written reply. 5. After receiving the registration materials of the participating enterprises, the village collective economic organizations, under the organization of local streets, conduct field visits to the headquarters of the participating enterprises and the comprehensive renovation project of the old villages, review the registration materials, and put forward a list of candidate cooperative enterprises. District Housing and Construction Bureau shall, jointly with the local street, organize the district public security bureau, the District Bureau of Industry and Commerce, the District Bureau of Agriculture and Rural Affairs, the District Market Supervision Bureau, the District Planning Resources Bureau and the District Taxation Bureau to conduct qualification examination on the list of candidate cooperative enterprises and registration materials put forward by the village collective economic organizations, and the local street will feed back the examination opinions to the village collective economic organizations within 10 working days. (II) Determination of cooperative intention enterprises 1. Within 20 natural days after the qualification examination of the candidate cooperative intention enterprises is passed, according to the Regulations on the Administration of Rural Collective Economic Organizations in Guangdong Province, the District Agriculture and Rural Bureau will guide the local neighborhood organizations to organize village collective economic organizations to hold a general meeting or a meeting of members’ representatives to vote on the enterprises that have signed up for the election and determine one cooperative intention enterprise. 2. Before voting, the village collective economic organization may hold a presentation on the candidate enterprises. The presentation order of the candidate enterprises shall be decided by lot, and the presentation time shall generally not exceed 20 minutes. Representatives of the candidate enterprises shall truthfully introduce the basic situation of the enterprises, competitive advantages and ideas for the renovation of the project, and shall not exaggerate words and attack other candidate enterprises, preach specific compensation standards, or conduct relevant publicity in violation of laws and regulations. Once found, they shall be disqualified from the presentation.3. When voting, the village collective economic organization shall hold a general meeting or a representative meeting of members to vote in accordance with the provisions of Article 10 of the Regulations on the Administration of Rural Collective Economic Organizations in Guangdong Province. Participants shall comply with the provisions of Article 10 of the Regulations on the Administration of Rural Collective Economic Organizations in Guangdong Province. If there is only one candidate enterprise, it can be determined as a cooperative enterprise if it is approved by more than half of the members present at the meeting or more than two-thirds of the members’ representatives; If there are more than one candidate enterprise, the enterprise with the highest number of votes and more than half of the members present or more than two-thirds of the members’ representatives will be selected as the cooperative intention enterprise; If the number of votes passed in the first round of voting does not reach more than half of the actual members or more than 2/3 of the members’ representatives, the top two enterprises with the highest number of votes in the first round of voting will be selected for the second round of voting on the spot, and those with more than half of the actual members or more than 2/3 of the members’ representatives will be identified as cooperative enterprises; If there is a tie for the highest number of votes in the first round, the enterprise with the highest tie will be voted in the second round on the spot. If the number of votes passed by the voting reaches more than half of the actual members or more than two-thirds of the members’ representatives, it will be determined as a cooperative enterprise. If the result of the second round of voting is that the number of votes passed by the candidate enterprises does not reach more than half of the actual members or more than 2/3 of the members’ representatives, and the enterprises with cooperative intentions cannot be selected, the work of introducing enterprises with cooperative intentions will be terminated. After 15 natural days, the village collective economic organizations can resume the introduction of cooperative enterprises.4. The village collective economic organization shall report the preliminary voting results to the local street and district housing construction bureau for review after the consent of the village collective party committee. After examination, the village collective economic organization will publicize the list of cooperative enterprises within the village area for more than 7 natural days, and record (photograph) the publicity process and results. 5. There is no objection at the expiration of the publicity period, and after being audited by the local street and district housing and construction bureau, the village collective economic organization will sign a cooperation intention agreement with the cooperative intention enterprise within 5 natural days; Within 10 natural days from the date of signing the cooperation intention agreement, the list of cooperative intention enterprises and the cooperation intention agreement shall be copied to the district government according to the procedures, and the list of cooperative intention enterprises shall be published within the village area. (3) The validity period of the cooperation intention agreement for task assessment shall not exceed 2 years in principle. Within three months after the signing of the cooperation intention agreement, the District Housing and Construction Bureau, local streets, village collective economic organizations and cooperative intention enterprises shall sign a supervision agreement for the renovation project. Enterprises that have signed cooperation intention agreements with village communities should cooperate with the government to sign supplementary supervision agreements. In addition to the necessary clauses, the supervision agreement should also stipulate that within the validity period of the cooperation intention agreement, the cooperative intention enterprises should complete the following tasks within the specified time: for the old villages that have started the basic data survey, they should cooperate with the village collective economic organizations to complete the work of inviting public investment and introducing cooperative enterprises within 18 months. For the old villages that have not started the basic data survey, we will cooperate with the village collective economic organizations to complete the work of inviting public investment and introducing cooperative enterprises within 24 months. If the related tasks are not completed according to the above node time,The District Housing and Construction Bureau or the local street will issue a supervision letter, and interview the main person in charge of the village collective economic organization and the person in charge of the cooperative enterprise. If the task has not been completed for two consecutive times, it will be handled according to the compulsory withdrawal mechanism. (IV) Management of performance bond If it is stipulated in the cooperation intention agreement that the enterprise pays the performance bond, the following contents can be agreed in the agreement at the same time: 1. The performance bond paid by the cooperative intention enterprise shall be deposited in the account jointly supervised by the village collective economic organization and the enterprise, and no one may withdraw or misappropriate it without the unanimous consent of the village collective economic organization and the enterprise; 2. If the village collective economic organization and the cooperative intention enterprise reach an agreement through consultation and are voted by the members’ congress, or meet the termination conditions stipulated in the cooperative intention agreement, the principal and interest of the performance bond shall be returned to the cooperative intention enterprise; 3. When the cooperative intention enterprise signs up for the follow-up cooperative enterprise’s open investment invitation, the performance bond paid can be converted into campaign deposit; If the performance bond is lower than the deposit amount required by the investment invitation documents, the difference shall be filled. Iv. process of introducing cooperative enterprises (I) preparation and preliminary examination, examination and approval of investment documents The village collective formulates investment documents for the open introduction of cooperative enterprises under the guidance of local streets. Upon the motion of the village collective party Committee, the first draft of the investment invitation document for the old village renewal and reconstruction project prepared by the village collective economic organization shall be submitted to the local street after the consent of the village collective party Committee, and the local street shall solicit the opinions of the functional departments in the member units of the district urban renewal leading group after the preliminary examination of the investment invitation document. If the local street is inconsistent with the administrative street of the village collective economic organization,It is also necessary to seek the opinions of the administrative street. According to their functions, all units put forward opinions on the first draft of investment promotion documents from the aspects of planning, industry and policy. The local street guides the village collective economic organizations to revise and improve the investment documents according to the feedback. The village collective economic organization will submit the revised draft of the investment invitation document (with feedback) to the District Housing and Construction Bureau according to the procedure, which will be reviewed and confirmed by the District Housing and Construction Bureau and submitted to the district urban renewal leading group meeting for approval. (II) Voting on Investment Promotion Documents If the meeting of the leading group for urban renewal in the district proposes amendments to the investment promotion documents, the village collective economic organizations will vote on the revised investment promotion documents; if there are no amendments, they will vote on the investment promotion documents that have been reviewed. Before voting, it should be announced in the village affairs column in advance, and the announcement time should be no less than 5 working days. After the members’ congress of the village collective economic organization votes, the village collective economic organization shall publicize the voting results and investment promotion documents in the village affairs public column within 3 natural days from the date of voting, and the publicity time shall not be less than 5 working days, and accept the supervision of the members of the village collective economic organization. At the same time, the District Housing and Construction Bureau shall send a copy to the Municipal Housing and Urban-Rural Development Bureau. (III) Announcement 1. The village collective economic organization entrusts the investment promotion agency to publish the announcement information in the Guangzhou Public Resource Trading Center, and the date of issuing the tender announcement for the introduction of cooperative enterprises shall not be less than 30 natural days from the bidding deadline. 2. The applicant cooperative enterprise shall submit the qualification examination materials and pay the campaign deposit according to the requirements of the investment announcement. (4) Qualification examination 1. After the deadline for registration,A qualification review team is organized by the investment promotion agency. The qualification examination team is composed of expert members, district functional departments, street representatives of the project territory and representatives of members of the village collective economic organizations, and conducts qualification examination and confirmation on the registered cooperative enterprises. The qualification review team consists of 7 members, including 2 experts, 1 representative of the District Housing and Construction Bureau, 1 representative of the District Planning and Resources Branch, 1 representative of the local street, and 2 representatives of the members of the village collective economic organization (which may be composed of representatives of the village collective party committee, social committee members or other members, and shall be determined by the leadership meeting of the village collective economic organization before the qualification review is confirmed). Expert members are drawn from the expert database of Guangzhou urban renewal by the investment promotion agency. The representative of the District Housing and Construction Bureau (a cadre at or above the official level) serves as the leader of the qualification review team. The qualification review team shall review the introduction conditions of cooperative enterprises and cooperative enterprises. Before the qualification examination, the application materials should be fully consulted by the departments of market supervision, taxation, land planning, urban management, education, health, culture, tourism and sports. 2. After passing the qualification examination, the qualification examination team will issue the qualification examination results, and the Guangzhou Public Resource Trading Center will confirm the candidate qualification of the cooperative enterprise and notify it to participate in the voting activities. The village collective economic organization shall announce the list of candidate cooperative enterprises through the village affairs column, and the announcement time shall not be less than 5 working days. 3. As long as there is no less than one enterprise that has passed the qualification examination, this open introduction of cooperative enterprises is effective. (5)Determination of cooperative enterprises 1. Village collective economic organizations shall hold a general meeting of members or a meeting of representatives of members in accordance with the provisions of Article 10 of the Regulations on the Administration of Rural Collective Economic Organizations in Guangdong Province, and vote on the candidate cooperative enterprises to determine the winning cooperative enterprises. 2. Before voting, the village collective economic organization may hold a presentation meeting of the candidate enterprises, and refer to the relevant provisions of point 2 of paragraph (2) of Article 3 of these Guidelines. 3. Voting procedures shall be implemented with reference to the relevant provisions in point 3 of paragraph (2) of Article 3 of these Guidelines. 4. If two rounds of voting fail to select a cooperative enterprise, the activity of introducing a cooperative enterprise will be terminated. It will take 15 natural days for village collective economic organizations to re-introduce cooperative enterprises according to these guidelines. (VI) Publicity of voting results Within three natural days after the voting results are studied by the village collective and reported to the village collective party committee for approval, the village collective economic organization shall publicize the voting results in the village affairs column, the project location and the Guangzhou Public Resource Trading Center for not less than five working days. And the publicity process and publicity results are recorded (photographed) on file. (VII) Signing a cooperation agreement 1. Upon the expiration of the publicity period, the winning cooperative enterprise shall pay the public resource transaction service fee according to the time and amount specified by the Guangzhou Public Resource Trading Center after receiving the notice from the Guangzhou Public Resource Trading Center. The village collective economic organization shall, within 5 natural days from the date of receiving the Confirmation of Transaction issued by Guangzhou Public Resources Trading Center, issue the Notice of Cooperative Transformation to the competing cooperative enterprises.And send a copy to the district housing and construction bureau and the local streets. 2. The village collective economic organization shall sign a cooperation agreement with the competing cooperative enterprise within the time specified in the investment invitation documents from the date of issuance of the Notice on Cooperative Transformation. The cooperation agreement shall specify the specific rights and responsibilities of the cooperative enterprise, and submit the cooperation agreement to the local street and district housing and construction bureau. Within 30 natural days from the date of signing the cooperation agreement, the local street will report the investment results to the district government and be responsible for publishing them on the portal website of the district government, and the District Housing and Construction Bureau will report the investment documents and investment results to the Municipal Housing and Urban-Rural Development Bureau. (VIII) Management of campaign deposit 1. A campaign deposit supervision account shall be set up as required, and the deposit shall be collected and deposited with the campaign deposit supervision account. Enterprises applying to participate in the election of cooperative enterprises shall pay the election deposit according to the prescribed amount before passing the qualification examination. 2. The village collective economic organization shall, within 30 working days from the date of the expiration of the publicity of the investment promotion results, return the campaign deposit of the uncompetitive cooperative enterprise and the interest on its bank deposits in the same period. After the signing of the cooperation agreement, the campaign bond of the winning cooperative enterprise will be converted into the performance bond of the cooperation agreement. (9) Within three months after the signing of the task assessment cooperation agreement, the District Housing and Construction Bureau, local streets, village collective economic organizations and cooperative enterprises shall sign a supervision agreement on the renovation project, clarify the construction and operation requirements of public facilities such as education and medical care in the renovation of villages in the city, and clearly introduce the specific requirements such as the type, quantity and economic benefits of industrial enterprises, the time of reaching production and the standard of reaching production, and stipulate the payment of bank performance bonds.And appoint corresponding departments to strengthen supervision during and after the event to ensure the contractual joint venture’s performance. The supervision agreement should also stipulate that within the validity period of the cooperation agreement, the cooperative enterprise should assist the village collective economic organizations to accelerate the renovation and reconstruction projects of old villages. In principle, it is required to complete the following tasks within the specified time: from the date of signing the cooperation agreement, the district planning scheme and the detailed planning modification scheme should be approved within 9 months; Complete the examination and approval of the implementation plan, vote on the compensation and resettlement plan and start the signing of the compensation and resettlement agreement within 18 months; Complete the signing of the compensation and resettlement agreement for the houses on the first phase of reconstruction and resettlement plots within 24 months; Start the first phase of reconstruction and resettlement housing construction within 30 months; Within 36 months, complete the relocation and delivery of houses on all rebuilt resettlement plots; Within 40 months, all the resettlement houses will be rebuilt and started construction; The reconstruction of resettlement houses will be basically completed within 60 months. In addition to the above-mentioned time nodes, we should reverse the construction period and refine the task nodes in accordance with the requirements of Guangzhou Work Plan for Deepening Urban Renewal and Promoting High-quality Development, combined with the actual situation of specific projects, to ensure the completion of the following assessment objectives: the old villages listed in the city’s "three-year implementation plan" and the old villages whose transformation implementation plans have been approved will basically complete the reconstruction and resettlement housing construction by the end of 2023; The old villages listed in the "three-year implementation plan" and whose transformation implementation plan has not been approved will start construction before the end of 2023, and the reconstruction of resettlement houses will be basically completed before the end of 2025; The old villages listed in the "Five-year Action Plan" of the city will be rebuilt and resettlement houses will start construction before the end of 2025.The reconstruction of resettlement houses will be basically completed by the end of 2030. If the relevant tasks are not completed according to the node time, the District Housing and Construction Bureau and the local streets will issue a supervision letter and interview the main person in charge of the village collective economic organization and the person in charge of the cooperative enterprise. If the tasks have not been completed after two consecutive supervision, they will be dealt with according to the mandatory withdrawal mechanism. V. Division of functions (I) Village collective economic organizations Village collective economic organizations are the main implementers of old village renovation projects, and they are also the main implementers of cooperative enterprises or cooperative enterprises that are openly introduced into old village renovation projects. In the open introduction of cooperative enterprises and enterprises with cooperative intentions, the announcement of decision-making motions and voting results should be reported to the village collective party committee for approval, and general party membership meeting should be organized to discuss and report relevant information. The village collective party committee should perform the duties of leadership, organization, overall planning and supervision, and organize the work of declaration and voting, including entrusting Guangzhou Public Resource Trading Center to issue investment announcement and conduct qualification examination on the participating enterprises, voting on the candidate enterprises, and finally signing an agreement with the determined cooperative enterprises or enterprises with cooperative intentions. (II) Territorial Streets Territorial streets are responsible for reviewing the information of cooperative intention enterprises submitted by village collective economic organizations and the drafted cooperative intention agreements, conducting preliminary examination of investment invitation documents prepared by village collective economic organizations, and supervising the whole process of openly introducing cooperative enterprises and cooperative intention enterprises, daily supervision and maintaining stability. (3) District Housing and Construction Bureau The District Housing and Construction Bureau cooperates with the street to review the information of the cooperative intention enterprise and the cooperative intention agreement.Review and confirm the investment invitation documents for introducing cooperative enterprises, and assist local streets to supervise and guide the whole process of openly introducing cooperative enterprises. Formulate format texts of series of documents such as investment invitation documents and cooperation framework agreements for rural collectives to refer to. (IV) Investment Promotion Agency The investment promotion agency is responsible for compiling investment promotion documents and organizing investment promotion according to its own requirements, and assisting the village collective economic organizations in determining candidate cooperative enterprises. (V) Guangzhou Public Resource Trading Center Guangzhou Public Resource Trading Center is responsible for issuing investment announcements, providing venues for qualification examination activities and publicizing the voting results. (six) the District Investment Promotion Bureau shall, after the establishment of the cooperative enterprise, clarify the contents and requirements of industrial introduction with the cooperative enterprise, so as to ensure substantial progress in the project construction within three years and substantial results in industrial introduction after the project construction. (VII) Other departments Other departments shall cooperate with each other to do guidance and related work within their respective functions. VI. Safeguard Measures (1) Establishing a supervision and supervision mechanism The Housing and Construction Bureau of the district and the local streets should strengthen the supervision and management of the open introduction of cooperative enterprises and cooperative enterprises in the old village cooperative transformation projects, focusing on strengthening the supervision and management of investment promotion activities; All the votes involved in this work guide shall be witnessed by the District Housing and Construction Bureau, the District Agriculture and Rural Bureau and the local street site; Where the village collective economic organizations or community monitoring stations should strengthen supervision, supervision committee should strengthen the supervision of village affairs, and can supervise all aspects of the whole process of old village reconstruction. (2)The investment documents, cooperation agreements and supervision agreements for establishing the mechanism of breach of contract and dishonesty withdrawal shall specify the liability for breach of contract and withdrawal of the cooperative enterprise (or cooperative intention enterprise). If the imported cooperative enterprises and cooperative intention enterprises fail to perform their duties conscientiously, fail to complete the project assessment task according to the node time specified in these guidelines, or have other behaviors that lead to the slow construction period of the old village reconstruction project and affect the implementation of the project, or under the circumstances specified in Articles 18 and 19 of the Guidelines for the Introduction and Exit of Cooperative Enterprises in the Reconstruction of Villages in Guangzhou (Sui Jian Gui Zi [2021] No.1), the village collective economic organizations will order the enterprises to withdraw after voting in accordance with democratic decision-making procedures. The Housing and Construction Bureau of the designated district of the district government strengthens the supervision of the implementation of the supervision agreement and urges the cooperative enterprises (cooperative enterprises) to perform their duties according to law. If the cooperative enterprise (cooperative intention enterprise) violates the supervision agreement and meets the withdrawal clause, the District Housing and Construction Bureau may also start the withdrawal procedure of the cooperative enterprise (cooperative intention enterprise) according to the supervision agreement. Enterprises that have been ordered to quit are not allowed to participate in the urban renewal and transformation work in Haizhu District. After the withdrawal of cooperative enterprises or cooperative intention enterprises, the district government will guide the village collective to start the selection of new cooperative enterprises or cooperative intention enterprises in the villages whose transformation work has not been completed. The early investment of the withdrawn cooperative enterprise or cooperative intention enterprise shall be compensated reasonably according to the agreement. (3) If the establishment of an opinion feedback mechanism has any objection to the process of introducing the cooperative enterprise, it may, within the period of publicity of the results,Query the village collective economic organization in writing. The village collective economic organization shall, within 5 working days from the date of receiving the written question, reply to the question. If you are dissatisfied with the reply or fail to receive the reply within the specified time, you can complain to the District Housing and Construction Bureau or the local street within 5 working days from the date of expiration of the reply. The District Housing and Construction Bureau or the territorial street shall decide whether to accept the complaint within 3 working days from the date of receiving it. If it is accepted, it shall take the lead in coordinating the relevant units to jointly study and make a reply to the complaint within 30 working days from the date of acceptance. If a question or complaint is raised within the time limit, it will not be accepted. VII. Supplementary Provisions The Housing and Construction Bureau of Haizhu District, Guangzhou shall be responsible for the interpretation of these work guidelines; It will be implemented as of the date of issuance and will be valid for 5 years. The basis of relevant laws and policies changes or expires, and shall be revised according to the implementation.

Let minors use the Internet well.

  The Regulations on the Protection of Minors’ Network was officially promulgated recently. This is the first comprehensive legislation on the protection of minors’ network in China, which reflects the great attention and cordial concern of the party and the state for the growth of minors, and marks that the legal construction of minors’ network protection in China has entered a new stage.

  As of June this year, the number of netizens in China has reached 1.079 billion, and the number of underage netizens has exceeded 191 million. Internet has expanded the space for minors to study and live, but some illegal and bad information also has a negative impact on minors’ physical and mental health. In addition, minors’ awareness and ability to use the network safely and reasonably is not strong, and it is necessary to strengthen the rule of law and build a new mechanism for the protection of minors’ network in the digital age to prevent personal information from being abused and addicted to the network.

  The "Regulations" adhere to the problem orientation and focus on the outstanding problems faced by minors’ network protection. For example, indulging in the Internet has seriously affected minors’ physical and mental health and normal study and life, and has become a hot topic of concern to the whole society. The "Regulations" clearly require network products and service providers to establish and improve the anti-addiction system, refine the real-name registration system regulations of online games, establish and improve the rules of anti-addiction games, and guard against and resist the adverse value tendencies such as traffic supremacy. For network service providers, whether to enhance user stickiness is a key indicator of the success of product design, which is a natural contradiction with preventing users from indulging. To this end, the "Regulations" put forward requirements for some network platform service providers that have a significant impact on minors, such as regularly evaluating the impact of network protection for minors, providing models or areas for minors, and formulating special platform rules.

  It should be pointed out that the "Regulations" do not simply position minors as protected persons, but regard them as important internet users, and fully respect their right to use the Internet. All the protective measures in the Regulations are aimed at supporting minors’ scientific, civilized, safe and rational use of the Internet, and it is clearly stipulated that it is strictly forbidden to interfere with minors’ addiction to the Internet in a way that infringes on their physical and mental health. This is the embodiment of the progress of legislative ideas in the new era.

  The promulgation of the "Regulations" has further improved and perfected the system of laws and regulations on juvenile protection, and together with comprehensive laws, juvenile-specific laws, relevant administrative regulations, local regulations, departmental rules and supporting judicial interpretations, it has built a legal barrier to safeguard the rights and interests of adolescents.

  The life of laws and regulations lies in their implementation. After the implementation of the Regulations, relevant government departments and enterprises, schools, families, industry organizations and news media should actively perform their duties in the network protection of minors, strengthen supervision and protection of minors’ network use, provide a safe and healthy network environment for minors, and create a clear network space. (This article Source: Economic Daily Author: Liu Liang)

Happy New Year in advance! The imported little brother Dimaxi first appeared on the stage of the Spring Festival Evening and joined hands with the strength singer.

  CCTV News:This year, three powerful singers in the pop music world have newly formed a group and made their debut on the stage of the Spring Festival Evening. Who are they? Let’s meet.

  Last year, singers Tia Ray, Di Mashi and Jam Hsiao were well known to the audience because they participated in the same variety show. In particular, Dimashi, a singer from Kazakstan, conquered the vast audience in China with the sound of nature, and was affectionately called "imported little brother" by fans. The common love for music made the three singers form a deep friendship. This time, they boarded the CCTV Spring Festival Evening in the form of a group and sang a Chinese song composed by Tia Ray.

  I feel very honored to be on the Spring Festival Gala,’ said Kazakh singer Dimashi. Jam Hsiao and Tia Ray are the best friends I have known since I came to China. Although they are very young, they have been loved by fans and achieved very high musical achievements. I am very happy to perform with them.

  Dimashi said that he has regarded China as his second home, and he has gradually integrated into the culture of China. Therefore, on the stage of the Spring Festival Evening, he must express his gratitude to the audience in China with Chinese songs.

  Kazakh singer Dimashi said that like a "shi", it has four tones, so it is not easy to master it well. Secondly, for China singers, they know the meaning of lyrics, so they will sing with great emotion. But for me, I can only read and sing according to its phonetic symbols, and it is really difficult to recite a complete Chinese song.

  Singer Tia Ray says reciting Chinese is particularly cute, isn’t Dimash right? I said yes, and then he gave me a proud look, that is, he said, "What do you think of my study?" And the three of us are very happy together, and everyone appreciates each other’s music, so I think there seems to be a magical chemical reaction between the three of us.

Dimaxi wishes everyone a happy New Year and a good year of the dog in advance.

Dimaxi wishes everyone a happy New Year and a good year of the dog in advance.

Police in Yingtan City, Jiangxi Province cracked a major case of spreading obscene videos by live webcast.

  CCTV News:Recently, Yingtan City, Jiangxi Province, cracked a case of spreading obscene videos by webcasting. Police investigations found that there were more than 200 pornographic webcasting platforms related to investigating live gangs.

 

  Not long ago, the police of Netan Detachment of Yingtan Public Security Bureau found out the webcast platforms such as Shooter, LT and Su He, which were suspected of spreading harmful information such as obscene videos. Police patrol track, quickly locked a pair of yingtan netizen Hu and his wife.

  Li Zhiru, a policeman of the Network Security Detachment of Yingtan Public Security Bureau.: "Hu and his wife are suspected of broadcasting obscene performances on a number of pornographic mobile APP platforms. His live broadcast time is every night until the early hours of the morning."

  After the clues were verified, the public security departments of Jiangxi Province and Yingtan City attached great importance to it and immediately set up a task force to carry out investigations.

  Li Zhiru, a policeman of the Network Security Detachment of Yingtan Public Security Bureau.: "In the crime scene of Hu and his wife, there are five or six mobile phones and five or six platforms for live broadcast. They are just pursuing the maximization of live broadcast benefits." 

  After preliminary investigation, since November 2017, Hu has joined the network obscene pornographic performance system composed of webcast platform, live broadcast family and anchor, acting as the anchor, performing obscene performances on the webcast platform through mobile phones, and participating in illegal interest sharing.

  Li Zhiru, a policeman of the Network Security Detachment of Yingtan Public Security Bureau.: "All the audience have to pay tickets to watch these performances, some are calculated by the venue, and some are calculated by the minute. The audience recharges the platform through Alipay and then gives gifts to the anchor. Gifts range from hundreds to thousands of dollars. The anchor has obtained these rewards. After recharging these rewards, he reported his profit statistics today to the head of the family, and the head of the family reported it to the platform. The platform counted it according to the background software program of her live broadcast platform. After verification, he detained 30% and 70% to the head of the family according to himself. The head of the family then transferred 10% and 60% of the total amount to the anchor through Alipay. "

Flash! CDE issued the Technical Guiding Principles for Pharmaceutical Research and Evaluation of Specific Human Immunoglobulin.

      In order to standardize and guide the R&D, production and registration of specific human immunoglobulin, and further clarify the technical evaluation standards, under the deployment of National Medical Products Administration, the Drug Testing Center organized and formulated the Technical Guiding Principles for Pharmaceutical Research and Evaluation of Specific Human Immunoglobulin (see Annex).
       According to the requirements of the Notice of the General Department of National Medical Products Administration on Printing and Distributing the Release Procedures of Drug Technical Guidelines (No.9 [2020] of the General Administration of Drug Administration), with the approval of National Medical Products Administration, it is hereby promulgated and shall come into force as of the date of promulgation.
       This is for your information.

       Appendix: Technical Guiding Principles for Pharmaceutical Research and Evaluation of Specific Human Immunoglobulin
National Medical Products Administration yaoshen center
May 20, 2022   
I. Overview

Specific human immunoglobulin (HIG) is a highly effective immunoglobulin preparation prepared from plasma containing specific antibodies.

The sources of plasma include plasma with high titer antibody after the patient recovered from infection with a pathogen, and plasma containing specific antibodies by hyperimmune injection of healthy blood donors, that is, injection of vaccines or other antigens to make the injected people produce antibodies. Specific human immunoglobulin (hereinafter referred to as "special immune product") is an indispensable blood product because it contains specific antibodies with high titer, and its effectiveness in preventing and treating specific diseases is better than that of ordinary human immunoglobulin.

In order to encourage, standardize and guide the research and development of special exemption products, this guiding principle is formulated with reference to the relevant technical requirements at home and abroad and combined with the actual situation in China. This guiding principle is only based on the current technical development and scientific cognition, aiming at the general pharmaceutical research technical requirements of special exemption products. The applicant/holder can also adopt other more effective methods and means according to the actual situation of the research and development of the exempted products, but it should conform to the law of drug research and development and provide scientific and reasonable basis to ensure the safety, effectiveness and controllable quality of the products. 

Second, the scope of application 

These guiding principles are applicable to the special immunity products made of specific antibody plasma obtained by direct screening of specific antibody of plasma donors and active immunization. They have similar product characteristics and pharmacological characteristics, and their pharmaceutical requirements are both common and different. At present, the varieties included in People’s Republic of China (PRC) Pharmacopoeia (hereinafter referred to as China Pharmacopoeia) include hepatitis B human immunoglobulin, rabies human immunoglobulin, tetanus human immunoglobulin, etc. The research and development and registration of special exemption products at home and abroad are shown in Schedule 1, and the modes of administration are divided into intravenous injection, intramuscular injection and subcutaneous injection.

III. General principles 

1. Security. 

Because of the particularity of blood products, there is a potential risk of virus pollution, and virus safety control is the core content of blood products quality control. The collection, inspection, storage, transportation, traceability and the immune requirements of plasma donors of the plasma exempted products shall conform to the provisions of "Plasma for Blood Products Production" in China Pharmacopoeia and "Quality Management Standard for Plasma Collection Stations". It is suggested that screening research on B19 and other pathogens should be carried out according to product characteristics and clinical users, especially some special varieties (such as anti-D immunoglobulin). It is suggested that the applicant/holder cooperate with relevant departments to carry out epidemiological monitoring in the area where the plasma station is located. Actively promote the detection technology of nucleic acid in raw plasma and mixed plasma, and formulate standards and requirements. Special attention should be paid to the epidemic situation and detection methods of new and sudden infectious diseases.

2. Specific antibody screening. 

The accuracy and reliability of specific antibody screening results is the key to ensure the quality of raw plasma. In the case of large-scale production, the amount of single plasma detection involved is large, so it is necessary to establish a suitable antibody titer detection method and fully verify it by the method in the early stage of research and development. Single plasma can be screened for specific antibodies by immunolabeling method, and the correlation between binding titer and neutralization titer can be established. The combined plasma, stock solution and preparation shall be tested for specific antibodies by the method specified in China Pharmacopoeia or the verified method. Usually, based on virus neutralization test (mouse neutralization test, micro-cell lesion count and plaque reduction test), immunolabeling test (enzyme labeling, fluorescence labeling, isotope labeling, etc.), hemagglutination inhibition test, immunodiffusion test, immunoturbidimetry test or other immune/biochemical tests, the research is carried out by quantitative and semi-quantitative methods based on reference materials.

3. Production technology 

The process development of this kind of products can refer to the process of similar products that have been listed, and platform technology can be used. The use of chromatography is encouraged to improve the purity of products, but the selection of chromatographic parameters and the influence of the quality of chromatographic resin on the quality of products should be fully considered, and the inactivation and removal ability of viruses by the process should be paid special attention to. The verification of virus inactivation/removal should meet the requirements of General Principles of China Pharmacopoeia "Virus Safety Control of Biological Products", "Technical Methods and Verification Guidelines for Virus Removal/Inactivation of Blood Products" and technical documents such as ICH and WHO.

Management rules and operating procedures should be established for personnel safety protection and wastes in the production process, bioactive substances and viruses should be inactivated according to proven inactivation treatment methods, and effective protective measures should be taken to protect operators to avoid risks such as virus transmission.

Four, pharmaceutical research and evaluation points 

(1) Raw plasma and materials for production 

1, plasma source and quality control 

Quality control of single plasma: single plasma must meet the relevant quality control requirements issued by the national health administrative department. Raw plasma used for production must have legal sources (plasma station certification documents, etc.) and pass inspection and quarantine, and should have complete reagent data (marketing certification documents, etc.) and screening records (antigens/antibodies/nucleic acids) for screening blood-borne infection markers.

Immune procedure: immune procedure and dosage of antigen used are the key factors to determine the concentration and titer of antibody in plasma. It is necessary to define the immunization methods. For example, when active immunization is carried out with approved vaccines or other antigens, these immunogens should have complete source certification information and batch information. The immunization program should refer to the requirements of vaccine instructions, or be formulated according to the immunogenicity of antigen and the reactivity of plasma donors, but the specific immunization program adopted should prove its safety. Subjects should have full right to know, and at the same time make corresponding countermeasures for possible problems. 

Quality control of mixed plasma: A certain amount of plasma should be mixed, which should meet the requirements of China Pharmacopoeia in combination with product characteristics. At present, ordinary people are required to mix the plasma of at least 1000 plasma donors. Specially exempted products generally require plasma mixing from at least 100 plasma donors, except for some special varieties (such as anti-D immunoglobulin products).

No matter the plasma obtained by active immunization with approved vaccine or immunogen or the plasma immunized after natural infection, the specific antibody content standard of each plasma and combined plasma should be formulated at the time of IND declaration. The plasma whose antibody level is up to the standard is used for plasma production. For varieties that have not been recorded in China Pharmacopoeia, there should be a clear basis and a proven detection method for determining the titer of specific antibodies in raw plasma and preparations. When NDA is declared for the varieties included in China Pharmacopoeia, the antibody titer standard should not be lower than the requirements of China Pharmacopoeia.

2. Raw materials for production 

Strict quality control of raw materials used in the production of special exemption products is a necessary measure to reduce the risk of contamination by exogenous factors or toxic impurities in products and avoid the activation of other factors in plasma. In addition to clear sources, quality standards and inspection reports, raw materials for production should also focus on the use of animal-derived raw materials (such as heparin) and avoid using animal-derived raw materials as much as possible. TSE/BSE risk assessment should be conducted for raw materials used in production. 

When using filter AIDS (perlite, diatomaceous earth, etc.), filter membranes and filter element materials in the separation process, it is necessary to establish appropriate quality control standards according to the requirements of different process stages, control the introduction risk of exogenous factors, control bacterial endotoxin and heavy metals, and formulate reasonable limit requirements. In addition, it is necessary to pay attention to the risk of residues that may be mixed into the final product and potentially harmful to human body, and control them if necessary.

(2) Production technology 

1. Stock solution 

The initial raw material of the special immunity products is raw plasma or plasma components. The modified Cohn method or KistlerNitschmann method can be used to separate the special immunity products, and other methods can also be used for separation and purification, such as octanoate precipitation and chromatography. 

The separation and purification process adopted should ensure that the physicochemical and biological properties of the product and the biological activity of the Fc segment of IgG are well preserved. The production process must avoid or eliminate the pollution of microorganisms (bacteria, viruses) and their metabolites (pyrogens) to the maximum extent. It is necessary to strengthen the control of production process and consider the influence of the removal of filter AIDS and the selection of filter media on the products. It should be paid attention to that IgG fractions obtained by different separation methods may contain higher levels of IgA and IgM. At the same time, attention should be paid to the rationality of sterilization and filtration steps, and the integrity of the filtered membrane should be checked.

It is necessary to specify the amount of slurry for pre-clinical, clinical samples and market-scale samples. Generally, continuous production should be carried out, and the production capacity of each process step should be matched with each other, and the processing should be completed at one time. In each process step, it is the key to determine the process control parameters and scope and meet the requirements. When using ethanol and other precipitation methods, it is necessary to control the quality of ethanol and other reagents, and study the protein concentration, temperature, pH value, ionic strength, treatment time and so on, so as to define the acceptable limit range. In the process of dissolution and precipitation of plasma components, avoiding IgG coprecipitation is the key to improve the product yield, especially the key indexes such as temperature and adding time should be fully studied to investigate the influence on the key quality indexes such as protein purity and molecular size distribution. When chromatographic method is used, it is necessary to optimize chromatographic conditions and determine reasonable parameters according to the nature and concentration of protein in the product, such as the capacity of chromatographic column, ionic strength of feed solution and buffer solution, pH value of buffer solution, flow rate, contact time and temperature, etc. The determination of these parameters should be based on the research data of process development, and limit standards and allowable ranges should be formulated. At the same time, it is necessary to study the cleaning and regeneration (service life) of chromatographic resin, the load of chromatographic column and the extract, especially the use of chromatographic packing with potentially harmful ligands. It is necessary to pay attention to the volume, protein concentration, recovery rate and electrophoretic purity of each separation and purification step, and evaluate the process-related impurities (such as ethanol, sedimentation aid, IgA, aluminum, heavy metal ions, etc.) and product-related impurities.(such as polymers, etc.). If necessary, in order to prove the ability of the process to remove impurities, it may be necessary to use standard addition test to evaluate the ability of the process to remove some potential pollutants. If operations that may affect product quality, such as temporary storage and transportation of intermediate products, need to be supported by necessary stability research data.

Encourage the use of innovative and improved processes (including the improvement of ethanol separation process) to improve the utilization rate of plasma and improve the quality of special exemption products. In the early stage of process development, attention should be paid to the identification of key process parameters, the integrity of process control in different separation stages and the rationality of process parameter setting. If the applicant/holder has already marketed products with the same separation and purification process, and the existing process research data and control parameters can be used for reference, the process verification of three batches of new special exemption products should be carried out. 

Considering the preciousness of plasma resources, the pilot-scale research data suitable for clinical trials can also be used for the declaration of IND stage. However, when applying for NDA, it is necessary to have complete commercial scale research data.

2. Preparation 

Clarify single prescription and batch prescription, and explain the basis of rationality of preparation prescription. Auxiliary materials suitable for medical use should be used, and the stability of the supply chain should be ensured. For accessories from multiple suppliers, it is necessary to carry out full research. For brand-new excipients that have not been used in similar preparations at home and abroad, a comprehensive study should be carried out and related declarations should be made. No bacteriostatic agent shall be added to the special exemption products for intravenous injection. Because some cosolvents (such as polysorbate 80) have the potential risk of causing allergic reaction and hemolysis reaction, safety evaluation should be carried out. The preparation process (such as stirring speed) should be studied. In principle, the preparation of semi-finished products should come from a batch of stock solutions. If different batches of stock solutions are used to prepare semi-finished products, the possible risks should be evaluated.

The temperature of products, the duration of packaging, the temperature and humidity of packaging environment should be controlled. Special exemption products involving freeze-drying technology should have data such as freeze-drying process parameters and freeze-drying curves verified by commercial batches, indicating the influence of freeze-drying technology on product quality, especially on biological activity.

3. Process verification 

For the products exempt from intramuscular injection, it is necessary to determine the process flow and key process parameters before NDA declaration, and continuously produce three batches of products to verify the stability of the process, so as to provide a supporting basis for the products to go on the market. For the special exemption products for intravenous injection, the process flow and key process parameters should be determined as far as possible before the confirmatory clinical trial, and the stability of the process should be verified by continuous production of three batches. If there are differences between clinical trial samples and commercial scale batches in terms of production technology or site, it is suggested to carry out change research, and it is suggested to carry out research and exploration on the worst process conditions at an appropriate stage, and it is necessary to prove that qualified products can be produced under the determined process parameters and quality control limits. If multiple production sites or production lines are involved, verification research should be carried out. 

(III) Virus safety and virus removal/inactivation verification 

The detection of single plasma and mixed plasma should meet the requirements of China Pharmacopoeia, and the number of cases of mixed plasma should meet the sensitivity requirements of the kit/detection method. For anti-D immunoglobulin, the nucleic acid load of B19 virus in plasma should be ensured to be less than <104 IU/ml.

Because of the differences in the ability of inactivation/removal of lipid-coated and non-coated viruses by various methods, it is recommended to use two virus inactivation/removal methods with different mechanisms to carry out verification, and to clarify the technical conditions and control parameters of virus inactivation/removal process steps, including product uniformity, upper and lower temperature limits, inactivation time, filtration pressure/speed/temperature/solution composition/membrane integrity, etc. Attention should be paid to the rationality of setting the position of deactivation/removal process steps. When selecting virus removal/inactivation method, the effect of virus inactivation/removal should be balanced with product activity and general safety. 

It is necessary to consider the potential interaction between inactivation steps, the influence of inactivation process on antibody integrity and clinical efficacy, whether new immunogens are formed and the risk of toxic residues that may be introduced. If the production process changes, which may affect the virus removal ability, it needs to be verified again. In addition, the samples used for inspection should be representative of the process. With the development of technology, some new methods of virus inactivation can also be applied in special exemption products, which need to be proved to be scientific and effective and fully verified.

If the products with the same process steps have been approved and registered, and the virus inactivation/removal process has been verified, the newly declared products will only change the mode of administration, and the products with the same production equipment, process and operation as the original products in commercial batches can not be subjected to virus inactivation/removal process repeatedly on the premise of meeting the relevant technical requirements such as Technical Methods and Verification Guidelines for Removing/Inactivating Viruses from Blood Products and Technical Guidelines for Pharmaceutical Change Research of Listed Biological Products.

In order to ensure the virus safety of the final product, we should consider the setting of plasma station from epidemiological data, strictly select plasma donors, screen plasma and manage the quarantine period, optimize the production process and add virus removal/inactivation steps, and evaluate the virus removal ability of the whole process steps of producing products. To evaluate the virus inactivation/removal ability of the production process and the maximum load of specific virus that may exist in the initial plasma, and to ensure the virus safety of the product to the greatest extent, it is necessary to ensure that the verification includes the worst case.

(D) Quality research and control 

1. Analysis of physical and chemical characteristics 

It is necessary to gradually improve the analysis of physical and chemical characteristics in combination with product types, preparation types and drug development stages. IND declaration can be made based on the preliminary research data of physical and chemical characteristics, and NDA declaration should be made by comparing the physical and chemical characteristics, including antibody integrity, antibody subtype distribution, circular dichroism analysis, etc.

2. Biological activity 

Biological activity research should be fully carried out, and it is suggested to study the correlation between binding titer and neutralization titer detection methods. From the aspects of supporting the rationality of the process and considering the influence of the process on the product, it is suggested to establish a method for detecting the biological function of Fc, and to study the sialic acid content of Fc segment in the development stage. Production technology, antibody titer, IgG polymer, IgG subclass, etc. will affect the results of biological function test of Fc. In addition, it is suggested to analyze the binding ability of Fc segment to immune cell surface receptors, the activation of complement function by Fc segment, and the regulation of phagocytosis.

3. Purity and impurities 

Attention should be paid to the components that affect the function of this kind of products, and the purity is generally not less than 95%. In addition to carrying out research on impurity residues and proving the ability of the process to remove impurities, the impurity level limits of batches at different stages (if there are clinical and commercial batches) should be set reasonably. It is suggested that a sensitive method should be used to control the content of impurity protein. 

Polymers produced during the preparation of special immunity products are related to anti-complement activity (ACA), and the content of IgG polymers should be controlled. In order to prevent patients with congenital IgA deficiency from causing serious allergic reaction after using special immunity products, the content of IgA should be controlled. The content of anti-A and anti-B hemagglutinin should be studied and the limit standard should be established to prevent hemolytic reaction caused by large amount of infusion. Encourage the detection of coagulation activator levels and establish standards. It is suggested that anti-D antibody detection should be carried out for intravenous special immunity products from special plasma sources. In addition, in order to prevent the risk of thrombosis, it is suggested to control the FXIa content of intravenous special immunity products and establish standards.

Encourage the detection of other miscellaneous proteins in blood, such as kallikrein activator, immunoglobulin M, transferrin, albumin, α1- antitrypsin, α2 macroglobulin, haptoglobin, α1- acidic glycoprotein, ceruloplasmin, fibrinogen, antithrombin III, plasminogen, fibronectin and C1 esterase inhibitor.

Special exemption products, especially those for intravenous injection, should also focus on the control of insoluble particles. Insoluble particles can not be metabolized in human body, and it is easy to induce thrombosis if they stay in tiny blood vessels. The content of aluminum should be controlled. Aluminum has potential risks to the central nervous system, bones and other organs, and this risk is related to the infusion dose.

4, quality analysis and standards 

The listed special exemption products should meet the requirements of China Pharmacopoeia, and the rationality of testing items should be fully considered for new special exemption products. Quality standards should be set reasonably according to the characteristics of products with different administration methods, such as intravenous special exemption products, and FXIa factor, aluminum ion and IgA content should be increased.

When applying for IND, special attention should be paid to antibody titer, harmful residues and other related testing items.

When applying for NDA, the quality standards of stock solution, semi-finished products (if any) and preparation should be reasonably drawn up based on the data of various research and development stages and stability inspection, on the basis of statistical analysis of multiple batches, combined with the requirements of China Pharmacopoeia and the situation of similar products, with emphasis on the quality control of potency, and more stringent internal control standards should be encouraged. Advanced and mature methods should be used for titer detection, and various complementary analysis methods should be encouraged for quality control in the early stage of research and development. If auxiliary materials such as maltose, polysorbate 80 and glycine are added to the preparation, it should be controlled in the quality standard of the preparation and its content range should be defined.

5, analysis method and methodology verification 

Combined with the characteristics of products, select a reasonable analysis method and carry out sufficient methodological verification to ensure the feasibility of the method.
At the time of IND declaration, at least the preliminary verification of antibody titer and harmful residue detection method should be completed.

When applying for NDA, a complete analysis method should be established and verified. Clarify the accuracy, precision (including repeatability, intermediate precision and reproducibility), specificity, detection limit, quantitative limit, linearity, range and durability of the determination method. Methods other than those in China Pharmacopoeia should be fully verified when applying for NDA. If the determination method is changed greatly, the scope of re-verification should be determined according to the degree of revision of the method.

Establishment and verification of antibody titer detection methods: research on product-specific antibody titer detection methods and standards should be carried out before research and development. It is suggested to study the correlation between binding titer and neutralization titer detection methods. Try to use the method of China Pharmacopoeia, and try to choose the classic and industry-standard method for those not included in China Pharmacopoeia. Clarify the test operation flow, test parameters, preparation and calibration of work standards and criteria for judging results. According to the antibody titer detection method itself, select appropriate indicators to carry out methodological verification and establish verification scheme. Generally speaking, in terms of linearity, the correlation coefficient of neutralization titer determination method should meet the pre-set acceptable standards. In terms of accuracy, the ratio between the actual titer of neutralizing antibody and the theoretical titer of serum with different dilution times is 1, or the slope of regression line in covariance analysis is parallel. In terms of precision, the coefficient of variation should be controlled within 30% as far as possible. In terms of durability, it is necessary to investigate the effects of cell density (generation), neutralization virus dose, neutralization reaction conditions and time, and different positions of orifice plates on the test results. In order to study the influence of possible degradation products and degradation pathways on titer determination, the samples can be destroyed by accelerated methods such as strong light irradiation, high temperature and high humidity. Encourage the use of working standards as quality control, reduce test interference factors, and improve the accuracy and reliability of results.

Verification of detection methods for hazardous residues: Usually, hazardous residues are at trace level, and the sensitivity of detection methods determines the reliability of the results. Encourage the use of more advanced methods and instruments with higher sensitivity based on the methods in China Pharmacopoeia, and pay attention to distinguish the detection limits of instruments and methods. The obtained detection limit and quantitative limit data must be verified by samples with similar contents.
say
Test process and detection limit results, including accuracy and precision verification data. The linear indexes such as recovery rate (%) and relative standard deviation (RSD%) should be listed as regression equation, correlation coefficient, residual square sum linear graph, etc. The range should be drawn up within 20% of the specified limit according to the preliminary measured data, and in general, various methods with different principles should be used to verify each other. Methodological verification of product-related impurities: Methodological verification shall be carried out according to the requirements of China Pharmacopoeia. If the commercial kit is used for residue detection, it is suggested to study the selection of detection kit (such as IgA detection), and the detection kit should explain the sensitivity, specificity, detection limit, quantitative limit and linear range. In general, the accuracy, precision, linear range, interference test, reference interval and other indicators of the kit should be verified. The variation coefficient of precision should be within 20%, the accuracy deviation should not exceed 10%, the linear range determination coefficient (R 2) should be ≥ 0.98, and the relative deviation of interference test should be less than 10%. Attention should be paid to identify the factors that affect the accuracy of the determination results during the release test of products, such as pH value, PK activity, ionic strength of product solution, reaction temperature, etc., which will affect the determination results of PKA, and low pH conditions may reduce the PKA activity of products. 

6, reference (standard)

The quality control reference of antibody titer should be established according to the requirements of relevant guiding principles. When applying for NDA, it is necessary to clarify the key information such as the source and quality control of reference materials, and the reference materials should be related to the samples used in clinical experiments, paying attention to the accuracy and traceability of assignment. If international/national standards are adopted, the information of standards used (source, batch, etc.) shall be specified. If it is a self-made reference, the preparation process, calibration and stability should be studied.

(5) Stability study 

Stability test runs through the whole product life cycle and is the basis for formulating product standards and expiration dates. The stability test should be carried out in accordance with the China Pharmacopoeia and the relevant guiding principles of stability research of biological products at home and abroad. In the declaration stage of IND, preliminary stability inspection can be conducted to ensure the quality of samples in clinical stage. Complete a comprehensive stability inspection before NDA declaration, select suitable packaging materials, define storage and transportation conditions, and formulate a reasonable validity period. The investigation of influencing factor test and accelerated test should be studied as far as possible until the product is unqualified. Long-term stability investigation should extend the observation time of products as much as possible. In general, the liquid dosage form should be placed upside down and upright for stability test. Products with different closed systems should be tested for stability respectively. If a new production site is introduced to produce intermediate products, unless there are other reasons, the stability research of intermediate products and finished products should be carried out. The activity of Fc segment is an important indicator of the effectiveness of this kind of products, so it is suggested to investigate the related stability. For the special exemption products in liquid dosage form, the thermal stability test should be carried out, and the visible foreign bodies should be checked. The results should meet the requirements of China Pharmacopoeia.

(6) Packaging and sealing container system 

The source and control standard of inner packaging materials should be clarified, and the compatibility and sealing of packaging materials should be studied in accordance with the relevant guiding principles such as Technical Guiding Principles for Compatibility Research of Chemical Injection with Medical Glass Packaging Container (Trial Implementation), Technical Guiding Principles for Compatibility Research of Chemical Injection with Plastic Packaging Materials (Trial Implementation) and the requirements of ICH related guidelines. Extracts, dissolved substances, sloughs, etc. shall meet the limit requirements. Pay attention to the influence of the extract of inner packing rubber stopper and glass bottle on the preparation. 

V. Explanation of nouns

1. Blood Products refer to therapeutic products derived from human blood or plasma, such as human albumin, human immunoglobulin, human coagulation factor, etc.

2. Human Normal Immunoglobulin (HNIG): also known as gamma globulin or multivalent immunoglobulin, is an immunoglobulin preparation separated from healthy human plasma by low-temperature ethanol protein separation method or other approved protein separation methods, including intravenous immunoglobulin, intramuscular immunoglobulin and subcutaneous immunoglobulin.

3. Specific human immunoglobulin (HIG): It is a high titer immunoglobulin preparation prepared from plasma containing specific antibodies. The sources of plasma include plasma with high titer antibody after the patient recovered from infection with a pathogen, and plasma containing specific antibodies by hyperimmune injection of healthy blood donors, that is, injection of vaccines or other antigens to make the injected people produce antibodies. Different from ordinary immunoglobulins, such preparations must have at least one high titer antibody for the prevention and treatment of specific diseases in clinic.

4. Anti-complement Activity (ACA): A substance in serum or tissue fluid that can nonspecific bind to complement and make it inactive, such as protease and ester. 

VI. References (omitted)

Sellers’ net profit in the first quarter turned positive, and new energy exploration achieved initial results in eight years.

Cyrus achieved a positive net profit in the first quarter of 2024. On April 29th, Cyrus announced that its revenue in the first quarter was 26.561 billion yuan, a year-on-year increase of 421.76%. The net profit attributable to shareholders of listed companies was 220 million yuan, and the gross profit margin in the first quarter increased to 21.5%.

For Cyrus, this means entering a benign development stage in the new energy vehicle track. At the press conference of Beijing Auto Show, Zhang Xinghai, the chairman of Cyrus Group, has set a higher goal for the future. "Cyrus is reshaping luxury with wisdom, exploring the’ new luxury’ of’ traditional luxury+technological luxury’, and letting more China people drive luxury cars made in China."

Strong growth in new energy vehicle business: Sellers’ net profit turned positive in the first quarter.

Sailis started from Silicon Valley in 2016 and transformed into a high-end intelligent electric vehicle track. After eight years of new energy exploration and three years of cross-border integration, it has built three electric vehicles. In the first quarter of this year, Sailis achieved a positive net profit, and its gross profit margin continued to improve to 21.5%, which also confirmed the initial success of its new energy vehicle strategy and became a strong growth engine to promote performance.

In contrast, Tesla, as a pioneer and leader of new energy vehicles in the world, took 17 years to make a profit; BYD experienced a long period of "increasing income without increasing profit" before it ushered in the harvest period; It took LI eight years to make a profit for the first time.

Looking back on 2023, the competition in China automobile market is extremely fierce, and the "price war" runs through. In the face of the serious involution market environment, the new energy automobile business of Cyrus ushered in an outbreak in the second half of the year. The data shows that the operating income in the fourth quarter of 2023 was 19.162 billion yuan, a year-on-year increase of 74.49%; In the fourth quarter, the sales volume of new energy vehicles was 82,700, up 88.39% year-on-year, and both the operating income and the sales volume of new energy vehicles reached record highs.

In the first quarter of this year, it continued to maintain a strong growth momentum, benefiting from the increase in sales of new energy vehicles. In the first quarter of 2024, the net cash flow generated by operating activities was 1.187 billion yuan. At the same time, technological innovation and large-scale production have gradually reduced the realization cost, and the gross profit margin in the first quarter has greatly improved, further promoting the company’s profit growth.

AITO series continues to sell well, technology research and development drives innovation.

Behind the substantial increase in performance, it is inseparable from the hot sales of AITO series products jointly designed by Kailisi and Huawei. The series of models represented by AITO’s new M7 and M9 became explosive when they went on the market. In the first quarter of this year, the cumulative sales volume of AITO’s entire department broke 80,000, ranking among the top five luxury brands in China market and becoming the highest ranked China brand in the list.

Up to now, the number of auto users in AITO has approached 300,000. With the listing of the new M5 in AITO, the product matrix of high-end smart cars continues to be rich, and the market scale is expected to be further expanded. Many institutional research reports are optimistic about the growth of Cyrus. China Merchants Securities believes that the sales of the new M7 and M9 in Wenjie continue to climb, and the new M5 in Wenjie is listed, and the company’s sales have entered a benign turning point, optimistic about the subsequent continuous heavy volume.

It is worth mentioning that under the extremely involuted environment of the industry, Sailis has always maintained its strategic strength, formed its first-Mover advantage and accumulated advantage through large-scale R&D investment, achieved a leap in product quality through technological innovation, and finally transformed scientific and technological achievements into enterprise benefits. The data shows that in 2023, the R&D investment was 3.348 billion yuan, accounting for 12.38% of the operating income, which is the deep-seated reason why Cyrus can cross the industrial ups and downs cycle and also played a key role in turning the net profit into a positive one.

The Cyrus Rubik’s Cube platform, which was unveiled at the 2024 Beijing Auto Show, integrates industry-leading technologies such as safety, power, chassis and software across domains, bringing users a "easy-to-drive, easy-to-use and super-safe" car experience. When China’s new energy vehicles enter the second half, their own technical accumulation and accurate prediction of the future will become the key to winning or losing. From this point of view, the future of Cyrus can be expected.

News of the price reduction of Xingyue L in Yangzhou, with the highest discount of 15,000! Act quickly.

[car home Yangzhou Preferential Promotion Channel] At present, the popular models of Geely Automobile are undergoing substantial preferential activities in Yangzhou. The highest discount has reached 15,000 yuan, and the lowest starting price has dropped to 122,200 yuan. If you want to buy the Star Yue L, you may as well hurry up and click the "Check the car price" button in the quotation form to get a higher discount.

扬州地区星越L降价消息,最高优惠1.5万!赶快行动

The design of Xingyue L is full of strength and modernity. The front face adopts a family-style air intake grille with sharp LED headlights to create a strong visual impact. The body lines are smooth and dynamic, and the overall style presents an atmospheric and steady image.

扬州地区星越L降价消息,最高优惠1.5万!赶快行动

Xingyue L has a body size of 4770mm*1895mm*1689mm and a wheelbase of 2845mm, providing a spacious interior space. The side lines of the car are smooth and gradually narrow from front to back. With the tyre size of 245/45 R20 and fashionable rim design, it creates a sporty appearance. The front and rear wheel tracks are 1610mm, ensuring the stability and handling of the vehicle.

扬州地区星越L降价消息,最高优惠1.5万!赶快行动

The interior style of Xingyue L adopts modern design, creating a simple and elegant atmosphere. The center console is equipped with a 12.3-inch touch screen, which supports voice recognition control of multimedia system, navigation, telephone, air conditioner and skylight, and is easy to operate and full of technology. The steering wheel is made of leather, which supports manual adjustment up and down and back and forth to ensure that the driver can find the most suitable holding posture. The front seats are made of imitation leather, and the main driver’s seat has the functions of fore-and-aft adjustment, backrest adjustment, height adjustment (4-way) and lumbar support (4-way). At the same time, it provides heating, ventilation and massage functions to provide a comfortable experience for drivers. The passenger seat also has the functions of fore-and-aft adjustment and backrest adjustment. The second row of seats supports backrest adjustment, and the reclining form is proportional reclining, which increases the flexibility of storage space. In addition, the car is equipped with two front USB and Type-C interfaces, two rear USB and Type-C interfaces, and the wireless charging function of the front mobile phone, which meets the charging needs of modern people for smart devices in the car.

扬州地区星越L降价消息,最高优惠1.5万!赶快行动

Xingyue L is equipped with a 2.0T 238 horsepower L4 engine with a maximum power of 175kW and a maximum torque of 350 N m.. Matching it is an 8-speed automatic manual transmission, which provides an excellent driving experience.

Car home car owners spoke highly of the appearance of the Star Yue L. He mentioned the tough appearance of the Star Yue L, especially the car lights and chrome-plated vertical bars, which are very durable and have outstanding texture, well-proportioned body joints and exquisite workmanship. The design of the waistline is layered, showing a sense of muscle, while the penetrating taillights at the rear of the car are highly recognizable when lit at night.

How fierce is the Dongfeng Warrior 917 Lorenz M800 Star Chariot?

Many times, as long as I hear the words "big guy", "off-road vehicle" and "land overlord", many fans may guess that I am going to talk about a hard-core off-road vehicle again. Yes, what we are going to talk about today is the brand-new model announced by Dongfeng Technology: Dongfeng Lorenz M800 Star Chariot. As a high-definition version of Warrior 917, this model was jointly built by Warrior Technology and Lorenz. Before the Chengdu Auto Show, we filmed this warrior 917 Lorenz M800 in the shed. Let’s reveal the secret for you and see how fierce this new car is!

Right front 45

Science fiction appearance, with great visual impact.

Although the Warrior 917 Lorenz M800 is based on the current Warrior 917, compared with the traditional hard-core off-road style of Warrior 917, the appearance design of the new car can be said to be a brave leap over the traditional automobile design boundary, which is very exaggerated and radical. Cybermech-style front face design, composite carbon fiber armored body, eye-catching custom-made probe lights on the roof, both practical and sci-fi sense.

Right back 45

Moreover, the interior layout is a perfect combination of luxury and hardliners. The embracing cockpit is equipped with a three-spoke, leather, metal and black piano paint decorative panel. With the design of push-rod gear shifting mechanism, beacon air conditioning outlet and pistol door handle, it gives people a feeling of interstellar hard-core combat cockpit. Suspended central control LCD and embedded co-pilot LCD screen also bring the most intuitive visual impact. And Dana’s brand-new Confidence series 16-speaker sound system further strengthens the luxurious style of Warrior 917 Lorenz M800, so that drivers and passengers can enjoy high-quality music experience while off-road.

Interior panorama

Ace technology, creating extreme off-road performance

As a hard-core off-road vehicle, the Warrior 917 Lorenz M800 has also been comprehensively improved in off-road performance. The vehicle is equipped with the magic carpet function of suspension +CDC damping and VMC chassis dynamic domain control technology, which supports six full-scene intelligent off-road modes. Equipped with the warrior M ATS all-terrain intelligent system, the warrior 917 Lorenz M800 can easily cope with any challenge, no matter whether it is a rugged mountain road or a muddy swamp. In addition, the new car also has advanced functions such as 10.6-degree rear wheel steer-by-wire and crab mode. The addition of these functions makes the vehicle control more flexible.

Shift lever

As for the core power of off-road vehicles that everyone is most concerned about, the Warrior 917 Lorenz M800 Extended Range Edition has a comprehensive horsepower of 816 horsepower, with an acceleration of 6 seconds at zero speed and a wheel torque of 11,592 Nm. This power configuration makes the M800 burst into amazing acceleration performance in an instant, and it can be used for both starting acceleration and high-speed cruising. At the same time, the comprehensive endurance of the vehicle far exceeds 800 kilometers, which dispels the mileage worries for the owners who travel long distances in the wild.

Ceiling trim

It has both hard-core technology and more emphasis on luxury and comfort. As a new benchmark for hard-core off-road jointly created by Warrior Technology and Lorenz, Warrior 917 Lorenz M800 will undoubtedly set off a new upsurge in the hard-core off-road market. At that time, this new car will also be unveiled at the Chengdu Auto Show, which opened on August 30th. Interested friends must not miss it!

Maybach S-class price reduction news in Yangzhou area, the reserve price 1.438 million! Quantity is limited

Welcome to [Autohome Yangzhou Promotion Channel] to bring you the latest automotive market trends. Now, the luxury sedan giant is launching an exciting promotion in the Yangzhou area. This highly regarded model is attracting consumers with cash discounts of up to 30,000 yuan, and the starting price has been reduced to 1.438 million yuan. This is a great opportunity not to be missed, and it is a real economic benefit for owners who seek high quality and distinguished experience. If you are interested in the Maybach S-Class, be sure to click the "Check Car Price" button below to get the most accurate market quotation and get higher preferential treatment.

扬州地区迈巴赫S级降价消息,底价143.8万!数量有限

The Maybach S-Class is a masterpiece of luxury sedans and stands out for its exquisite craftsmanship and noble temperament. The front face is designed to be grand and solemn, and the streamlined silhouette reflects the perfect combination of elegance and power. The iconic double air intake grille is decorated with chrome, and every detail shows luxury and elegance. The overall style blends modern technology and classic aesthetics, and the body lines are smooth, showing a low-key and luxurious visual effect. No matter from which angle, people feel the unique charm of the Maybach S-Class.

扬州地区迈巴赫S级降价消息,底价143.8万!数量有限

The Maybach S-Class stands out in its elegant body proportions, with a length of 5470mm, a width of 1921mm, a height of 1510mm, and a wheelbase of 3396mm, ensuring a spacious ride in the car. The side lines are smooth and full of power, with front and rear wheels of 1655mm and 1683mm respectively. The carefully matched tire size 255/45 R19, with a chic wheel design, not only enhances the driving stability, but also adds a bit of luxury.

扬州地区迈巴赫S级降价消息,底价143.8万!数量有限

The Maybach S-Class interior is like a luxurious work of art, showing unparalleled luxury and comfort. Its steering wheel is made of high-grade leather, which not only feels delicate to the touch, but also supports electric up and down + front and rear adjustment to adapt to the individual needs of the driver. The center is equipped with a 12.8-inch central control screen, integrated multimedia system, navigation and phone functions, and has automatic speech recognition control to provide a convenient interactive experience for the driver. The seats are made of top-of-the-line leather, and the seat adjustment functions are rich, including front and rear, backrest, high and low, leg rest and waist support (4-way), providing comprehensive comfort support. At the same time, the front seats are also equipped with heating, ventilation and electric memory functions to ensure passengers have the ultimate ride enjoyment. Whether it is technological configuration or user-friendly design, the Maybach S-Class demonstrates its dignity and thoughtfulness as a luxury sedan.

扬州地区迈巴赫S级降价消息,底价143.8万!数量有限

The Maybach S-Class is equipped with a 3.0T turbocharged engine capable of outputting a powerful 380 horsepower and a maximum torque of 500 N. m. This efficient engine, combined with a 9-speed manual transmission, ensures smooth power transmission and driving experience. Its maximum power of 380 kW provides a surging power support for this luxury car series.

Overall, the Autohome owner spoke highly of the appearance of the Maybach S-Class. He emphasized the domineering and detailed treatment of the front of the car, especially the personalized air intake grille and double-parquet paint, which allowed the vehicle to show an unparalleled luxury aura on the road, and the return rate was quite high. This undoubtedly confirms that the Maybach S-Class is a model of luxury cars, not only unique in design, but also satisfying the owner’s pursuit of unique taste and noble experience.

Jolin Tsai demonstrates 180-degree bending stunt and personally interprets popular matching


Guests perform popular matches



Jolin Tsai and Tao Jingying


  On April 9, the program "College Students Are There" hosted by Tao Jingying invited Asian diva Jolin Tsai as a guest, and as a "pop diva" in the program, she instructed college students how to dress in fashion and wear exquisite curves; she also personally demonstrated how to paint nails and match accessories.


  In the eyes of college students, Jolin Tsai is not just "pop queen" or "song queen", but also "dance queen".


  In the latest music video, Jolin Tsai is even more amazing in performing ballet and jazz dance that went to the United States to study. College students have long imitated these dance steps on the spot. "The process of practicing dance is really hard, but in order to make your performance more perfect, you can only practice constantly. Even if you fall, you can get up immediately and practice again."


  Jolin Tsai also demonstrated a 180-degree bending with her head on her knees on the spot, which made the college students present even more amazed. It proved that the queen’s success was paid for by a lot of sweat.

Editor in charge: Wang Xin