The employees of this pharmaceutical company are very profitable, with a per capita income of nearly 460,000.

In the first half of the year, the characteristics of "differentiation" of CRO were prominent, and the growth rate of CRO was higher before clinic.

On July 2nd, CDE issued the Guiding Principles for Clinical Research and Development of Anti-tumor Drugs Oriented by Clinical Value, which triggered the CRO concept stocks in A-share and Hong Kong stock markets to plummet.

 

In fact, the release of the "new regulations on anticancer drugs" is a natural product of the transformation of China’s pharmaceutical industry from generic drugs to innovative drugs, from paying too much attention to the development of Me too drugs to the development of First in class or Best in class drugs, which also makes the CRO plate "differentiated". The trend has obviously accelerated.

 

As of August 30th, nine CRO companies including Wuxi PharmaTech, Kanglong Chenghua, Tiger Medicine, Zhaoyan New Medicine, Medici, Yaoshi Technology, Chengdu Pioneer, Ruizhi Medicine and Boji Medicine have disclosed the results of the interim report in 2021. This paper will select the key companies for comprehensive analysis.

Pre-clinical CRO or CXO faucet increased even more.

 

On the whole, as of the close of August 27th, 2021, there were only three CRO companies with a total market value of more than 100 billion yuan: WuXi PharmaTech (383.7 billion yuan), Kanglong Huacheng (154 billion yuan) and Tiger Pharmaceuticals (119.1 billion yuan), and two companies with a total market value of less than 10 billion yuan: Ruizhi Pharmaceuticals (6.924 billion yuan) and BoJi Pharmaceuticals (2.822 billion yuan). 

 

1. Tiger Medicine: The total market value decreased the most, and the increase was at the bottom.


Tiger Medicine, a leading clinical trial research service, had a total market value of 145.267 billion yuan at the beginning of the year (January 4, 2021), and the latest total market value was 119.1 billion yuan at the close of August 27, and the total market value has dropped by 26.167 billion yuan since the beginning of the year. The stock price dropped by 15.39%, which was the biggest drop among the three hundred billion CRO leaders, and ranked the bottom in the CRO industry.

In terms of performance, Tiger Pharmaceuticals achieved a total revenue of 2.056 billion yuan in the first half of the year, a year-on-year increase of 41.62%; The net profit was 1.255 billion yuan, a year-on-year increase of 25.65%; Deducting non-net profit was 543 million yuan, up 79.1% year-on-year. In the second quarter, the net profit was 799 million yuan, a year-on-year increase of 7.48%.

In terms of main business, the company’s clinical trial technical services, clinical trial related services and laboratory services achieved revenues of 1.034 billion and 1.016 billion respectively in the first half of the year, up by 45.36% and 38.43% year-on-year.

At the same time, in terms of non-main business income, the company realized investment income of 113 million yuan in the first half of the year, accounting for 6.65% of the total profit; The gains and losses from changes in fair value reached 906 million yuan, accounting for 53.53% of the total profits, which were mainly due to the investment income confirmed during the holding period and disposal of other non-current financial assets of the company during the reporting period.

 

2. Kanglong Chenghua: The total market value increased the most.


The total market value of Kanglong Huacheng at the beginning of the year was 94.919 billion yuan. As of the close of August 27th, the latest total market value reached 154 billion yuan, an increase of 59.081 billion yuan, which is almost equivalent to the market value of Zhaoyan New Medicine (53.86 billion yuan) and Wise Medicine (6.924 billion yuan).

Secondly, the total market value of Wuxi PharmaTech and Medici increased by 50.22 billion yuan and 31.4 billion yuan respectively compared with the beginning of the year, ranking second and third.

 

3. Medici: The stock price and total market value increased the most. 


The share price of Medici rose as high as 323.05% compared with the beginning of the year, and the total market value also increased by 31.4 billion yuan, with an increase rate of 324.42%, ranking first.

The financial report shows that Medeci achieved total revenue of 485 million yuan in the first half of the year, an increase of 86.26% year-on-year; The net profit of returning to the mother was 113 million yuan, a year-on-year increase of 142.29%, ranking among the top in the industry, and its performance was quite beautiful.

In the first half of 2021, thanks to the sustained growth of domestic and international drug R&D boom, the business performance of Medeci achieved steady growth. The two main businesses, drug discovery, pharmaceutical research and preclinical research, achieved revenues of 260 million and 225 million, respectively, which increased by 78.59% and 95.38% year-on-year.

 

To sum up, Wuxi PharmaTech and Kanglong Chenghua, which realize the whole industrial chain of CXO, have gained 15.06% and 62.24% respectively year-to-date by virtue of their high competitive barriers.

At the same time, the growth rate of preclinical CRO business is also quite high. The molecular block leader Yaoshi Technology has increased by 56.96% year-to-date, the drug safety evaluation leader Zhaoyan new drug has increased by 93.39%, and the increase rate of Medici is as high as 323.05%.

This means that the CRO plate has shown an obvious performance "differentiation" market.

 

Performance differentiation is obvious: WuXi PharmaTech has the highest revenue scale and Medici has the fastest growth rate.

 

On the whole, the growth rate of total revenue and net profit of these nine CRO companies both achieved positive growth in the first half of 2021, with a total revenue and net profit of 18.639 billion yuan and 5.183 billion yuan respectively.

 

1. WuXi PharmaTech: The scale of total revenue and net profit income is the highest. 


In the first half of 2021, Wuxi PharmaTech achieved a total revenue of 10.537 billion yuan, a year-on-year increase of 45.71%; The net profit was 2.675 billion yuan, a year-on-year increase of 55.79%.

WuXi PharmaTech’s main business is divided into laboratory services in China, contract production R&D services (CDMO), clinical research and other CRO services, and laboratory services in the United States. In the first half of the year, the revenue was 5.487 billion yuan, 3.599 billion yuan, 783 million yuan and 659 million yuan respectively.

Among them, the negative impact of clinical research and other CRO services caused by the domestic COVID-19 epidemic has been basically removed, showing a substantial increase compared with the comparable period: the revenue in the first half of the year was 783 million yuan, up 56.51% year-on-year.

During the reporting period, Wuxi PharmaTech Clinical Trial Services (CDS) team provided clinical trial development services for more than 170 projects in China and the United States. At the same time, it helped customers to complete three new drug listing registrations and five clinical research applications. Help five ADC projects achieve important milestones and a number of clinical research and development for COVID-19 products.

 

2. Medici: The growth rate of total revenue and net profit is the highest.


Although Yaoshi Technology achieved a net profit of 381 million yuan in the first half of the year, the year-on-year growth rate of net profit was as high as 336.5%. However, after deducting the non-recurring profit and loss of 236 million yuan, the non-net profit was 145 million yuan, an increase of 77.16%.

Among the non-recurring gains and losses of 236 million yuan of Yaoshi Technology, the highest proportion is that Yaoshi Technology completed the acquisition of Zhejiang Huishi, a CDMO company, in April 2021, and the gains generated by re-measuring the equity held before the purchase date at fair value amounted to 222 million yuan.

Relatively speaking, the profit quality of Medici is higher: the total revenue in the first half of the year was 485 million yuan, up 86.26% year-on-year; The net profit returned to the mother was 113 million yuan, a year-on-year increase of 142.29%, and the non-net profit was 110 million yuan, a substantial increase of 150.14%.

Composition of revenue in Medici

Source: 2021 Mid-year Report

During the reporting period, the number of new orders signed by Medeci maintained a good growth trend, with the amount of new orders reaching 1.026 billion yuan, with a growth rate of 93.64%. Sufficient orders laid a good foundation for future development. The company has provided drug research and development services to more than 1,100 customers at home and abroad, and added 161 customers during the reporting period.

During the reporting period, drug discovery and pharmaceutical research services signed 476 million yuan, an increase of 85.65%. Among them, 321 million yuan was newly signed for drug discovery, up 106.78% year-on-year; The number of newly signed orders for pharmaceutical research was 155 million yuan, a year-on-year increase of 53.29%.

 

3. Wise Medicine: the net profit and its growth rate are the lowest. 


Ruizhi Medicine is mainly engaged in the research and development, production and sales of CRO and CMO, series of prebiotic products such as fructooligosaccharides and galactooligosaccharides, and micro-ecological medical services.

In the first half of 2021, Ruizhi Pharmaceutical achieved a total revenue of 845 million yuan, a year-on-year increase of 26.14%, but its net profit was only 5.138 million yuan, a year-on-year decrease of 87.43%. Deducting non-net profit was a loss of 1,007,800 yuan, down 103.26% year-on-year.

During the reporting period, the company’s pharmaceutical R&D and production outsourcing services (CRO/CDMO) sector achieved operating income of 684 million yuan, accounting for 81% of the company’s total revenue. Among them, preclinical drug R&D outsourcing service (preclinical CRO), as an important part of pharmaceutical R&D and production outsourcing service (CRO/CDMO), achieved an operating income of 578 million yuan during the reporting period, accounting for 84% of CRO/CDMO.

 

To sum up, leading CRO enterprises that realize the whole industrial chain of CXO, establish platform advantages, or specialize in clinical research business have higher income scale and stable performance growth rate.

However, in preclinical research such as drug safety evaluation, molecular building blocks, drug discovery and pharmaceutical research services, the CRO leader with competitive advantage has been established. Although the income scale is low, the performance growth rate is very fast.

WuXi PharmaTech invested the most in R&D, and Chengdu Pioneer was the most willing to invest in R&D.

 

The key to WuXi PharmaTech’s brilliant performance lies in its strong R&D strength and strong team support.

Specifically, WuXi PharmaTech’s R&D investment in the first half of 2021 reached 404 million yuan, an increase of 21.29% over the same period of last year, mainly due to the company’s commitment to platform empowerment, including enzyme catalysis, flow chemistry, etc., and focused on a series of new capacity-building R&D activities such as AI reverse synthesis and resource sequencing algorithm development..



However, Chengdu Pioneer is the most willing to invest in R&D. In the first half of the year, it invested 33.5215 million yuan in R&D. Although it decreased by 27.92% compared with last year, the R&D expense ratio (the ratio of R&D investment to operating income) is still as high as 21.43%. At the same time, the gross profit margin of sales is as high as 52.2%.

Chengdu Pioneer’s main business is to provide research and development services in the early drug discovery stage and transfer of new drug research and development projects. The product types include DEL screening services, DEL library customization services, chemical synthesis services, and new drug research and development project transfer.

During the reporting period, Chengdu Pioneer increased the introduction of R&D personnel in related fields of core technology platforms, enriched the R&D team, and maintained the company’s R&D innovation capability. The number of R&D personnel increased to 379, accounting for 82.93% of the total number of the company. At the same time, by increasing R&D investment and expanding business cooperation, we will continue to strengthen the construction of its core technology platform -DNA coding compound library, and optimize the trillion-dollar DEL new molecular entity library.

 

Chengdu Pilot R&D Investment Table

Source: 2021 Mid-year Report

In addition, Boji Medicine (9.92%), Yaoshi Technology (8.21%) and Medici (7.01%) have high R&D expense rates. In the first half of the year, the R&D personnel of Wuxi PharmaTech and Medici also accounted for 82.88% and 85.48% of the total number of the company respectively.

Among them, Medici’s R&D investment in the first half of the year increased by 77.04% compared with last year, mainly due to the company’s continuous increase in investment in independent R&D projects in order to improve its R&D service capabilities and business undertaking capabilities and enhance its competitive advantage.

During the reporting period, the company expanded the construction scale and application of protein Degradation Technology (PROTAC) platform; Establish a research and development platform for small molecule drug discovery and a safety evaluation system for scale-up production process that meets the requirements of international norms; Continue to promote the improvement of new biotechnological drugs (including stem cells, CAR-T cells, ADC drugs, oncolytic viruses and other gene therapy products, as well as mRNA vaccines, etc.), and the construction of a technical platform for pre-clinical effectiveness and safety evaluation.

 

Among many CRO companies, employees of Yaoshi Technology can make the most money. In the first half of this year, the per capita income and per capita profit were as high as 454,000 yuan/person and 278,000 yuan/person respectively, mainly because the company actively expanded the market, increased sales orders and enhanced delivery capacity.

During the reporting period, in addition to the derivative growth of mid-and late-stage projects, Pharmaceutical Stone Technology accumulated a large number of early projects, forming a sustainable growth project pipeline. Among the projects undertaken by Pharmaceutical Stone Technology in the first half of the year, more than 320 were in pre-clinical stage to clinical stage II, and 29 were in clinical stage III to commercialization stage; In addition to the above projects, there are more than 350 projects above the kilogram level.

At the same time, Yaoshi Technology continues to expand its service customer base, especially small and medium-sized biotech companies. During the reporting period, the number of customers who formed orders was 722, a year-on-year increase of 5%; There were 105 terminal customers (including only domestic and foreign pharmaceutical companies and small and medium-sized innovative drug companies) above the kilogram level, with a year-on-year increase of 25%; There were 27 customers with sales of more than 5 million, a year-on-year increase of 42%.

To sum up, in the first half of 2021, due to the influence of policies and significant differences in performance, CRO companies showed obvious "differentiation" in the capital market.

Wuxi pharmatech and Kanglong Chenghua occupy the platform advantages of the whole industrial chain of CXO, and maintain the leading position of the strong. Pharmaceutical stone technology, Zhaoyan new drugs and Medicines, which have been engaged in preclinical research business for many years and established competitive advantages, are also favored by the capital market.

On the whole, under the background of accelerating the transformation from generic drugs to innovative drugs in China, high-quality CRO companies will still maintain a high degree of prosperity for a long time and have long-term investment value.

Source: Yaozhi. com

Author: Zongge 2025

Typesetting: Janessa

Editor: Adam

National Health and Wellness Commission: The number of imported cases cured and discharged on April 27th is the highest since the outbreak.

  Cctv newsOn April 28th, the joint prevention and control mechanism of the State Council held a press conference to introduce the development of agriculture and rural economy during the epidemic and answer questions from reporters.

  Mi Feng, spokesperson of the National Health and Wellness Commission and deputy director of the Propaganda Department, reported the epidemic situation.

  0: 00 on April 27th — At 2400 hours, the provinces (autonomous regions and municipalities) and Xinjiang Production and Construction Corps reported: 6 newly confirmed cases, including 3 imported cases, 2 in Shanghai and 1 in Inner Mongolia; 3 cases were local cases in Heilongjiang; No new deaths; One suspected case was added, which was imported from overseas to Shanghai. On that day, 81 new cases were cured and discharged, 915 people were released from close contact with medical observation, and 2 cases of severe cases were reduced.

  There are 552 confirmed cases imported from abroad, including 21 severe cases; There are 6 suspected cases. A total of 1639 cases were diagnosed, and 1087 cases were cured and discharged, with no death.

  As of 24: 00 on April 27, according to the reports of provinces (autonomous regions and municipalities) and Xinjiang Production and Construction Corps, there are 648 confirmed cases, including 50 severe cases; A total of 77,555 discharged cases were cured, 4,633 cases died, 82,836 confirmed cases were reported, and 9 cases were suspected. A total of 731015 close contacts were tracked, and 8014 close contacts were still under medical observation.

  There were no new and existing confirmed and suspected cases and no new deaths in Hubei on that day. A total of 63,616 discharged cases were cured, including 46,464 cases in Wuhan; There were 4512 cumulative deaths, including 3869 in Wuhan; A total of 68,128 cases were confirmed, including 50,333 cases in Wuhan.

  Reports from provinces (autonomous regions and municipalities) and Xinjiang Production and Construction Corps: 40 new asymptomatic infected people, including 3 imported from abroad; There was no confirmed case on that day; On the same day, 17 cases were released from medical observation, including 4 cases imported from abroad; 997 cases of asymptomatic infection are still under medical observation, including 130 cases imported from abroad.

  A total of 1511 confirmed cases were received from Hong Kong, Macao and Taiwan. Among them, there are 1037 cases in Hong Kong Special Administrative Region, 45 cases in Macao Special Administrative Region and 429 cases in Taiwan Province.

  On April 27, there were no new deaths in the country for 13 consecutive days, and the number of imported cases cured and discharged on that day was the highest since the outbreak; However, for 21 consecutive days, there have been reports of newly confirmed local cases. In some places, imported related cases and multiple clustered epidemics have occurred continuously. It is necessary to continue to strengthen the weak links in prevention and control, resolutely block the spread of the epidemic, and accurately grasp the internal defense rebound.

Besides bats, pigtail rats also have echolocation ability! Researcher: It is expected to help the blind.

With a pink nose, small eyes, wide and flexible ears and a broom-like tail, the pig-tailed mouse, known as the "blind mouse", has an echolocation ability.

Recently, researchers from Kunming Institute of Zoology, Chinese Academy of Sciences came to this conclusion.

The research groups of Shi Peng, Jiang Xuelong and Liu Zhen, the State Key Laboratory of Genetic Resources and Evolution of the Institute, jointly tackled the problem, and confirmed that the species of the genus Rodent has the ability of echolocation by integrating several independent evidences of ethology, anatomy, genomics and gene function experiments.

"In addition to the well-known bats, toothed whales, etc., pigtail rats also have this ability, which is amazing in itself!" On July 5th, one of the researchers, Dr. Liu Qi from Shi Peng’s research group, was interviewed by The Paper (www.thepaper.cn) and introduced that the research on echolocation ability of pigtail rats lasted for about 4 years. This study is expected to make the pig-tailed rat become a new experimental animal to study the neural circuits of sound, hearing and echolocation. He also hopes that the research results can be applied to artificial intelligence in the future, such as improving auto-driving and blind-assisted navigation.

"Are there other mammals that have this ability but have not been discovered?" Liu Qi believes that there is still a lot of room for the research and application of echolocation, and the research on pig-tailed mice is only the beginning.

The experiment lasted for nearly four years, and the researchers stayed up late with the pig-tailed rats.

The nose is pink, the eyes are small, the ears are wide and very flexible, just like bats, they will swing back and forth and collect sounds in different directions. Its tail is very long, shaped like a broom, and there is a pinch of white hair at the end of it.

This is Liu Qi’s research object-pigtail rat, which is also called "blind rat" because of its small eyes. It belongs to the genus pigtail rat of Rodent Echinopodidae.

Liu Qi studied the echolocation ability of pig-tailed rats. Echo location refers to a directional behavior of animals in navigation, foraging and other activities by comparing the information difference between sending sound waves and receiving echoes.

As early as 2017, Liu Qi had already started this research.

At that time, after he did some basic work, the experiment had preliminary research results. He organized the experimental content into an English manuscript and sent it to secience magazine in the form of a short article. Journals have given great affirmation to this research achievement and shown great interest, which has given them great confidence.

"In the later process, we supplemented many experiments according to the requirements of the magazine and constantly enriched and improved the paper." Liu Qi said that on the one hand, it is necessary to obtain accurate experimental evidence from many aspects, on the other hand, the workload of each experiment is very large, including the subsequent papers being revised many times, so the whole project involves a long time, and it is a joint effort of multiple research teams.

Liu Qi introduced that the correspondence authors Shi Peng and Liu Zhen’s research group have been engaged in the research on the convergent evolution and molecular genetic mechanism of echo localization for a long time, and have published many heavyweight research results. Another cooperative team, researcher Jiang Xuelong, who is also the correspondent of the paper, is engaged in the research on the behavioral ecology, phylogeny and classification of pig-tailed rats. This research is the result of joint research by three research groups.

Although there are three top teams in the joint experiment, there are many difficulties in the experiment.

Liu Qi introduced that the first difficulty comes from the research object-the pig-tailed rat. Before the study, they didn’t know much about the living habits of this kind of wild animal, such as what it eats, where it lives, whether it lives in groups, what its nest looks like and its activity time.

Secondly, the wild population of pigtail rat is not large, so it is a big problem to catch it and catch a certain number of live pigtail rats when doing experiments with it.

At the same time, the researchers have no experience in raising pigs. After catching a certain number of pigs, they don’t know how to raise them. They are worried that the artificially created conditions can’t make pigs behave naturally.

However, with the advancement of the experiment, solutions have been found to these difficulties.

What makes Liu Qi feel very interesting is that in the experiment, they found that animals such as pigtail rats are nocturnal. They sleep during the day and are more active at night. Therefore, in the process of behavioral experiments, researchers arrange experiments at night, and sometimes they have to work all night to complete an experiment.

The echolocation function of small-eyed "blind mouse"

Liu Qi said that in the experiment, they recorded the short-term, frequency-modulated and high-frequency sound waves (peak frequency ~98 kHz) regularly emitted by the pig-tailed rats during movement. In dark environment, pigtail rats will emit higher ultrasonic velocity in complex space environment and when avoiding obstacles. All these results show that the ultrasonic waves emitted by pigtail rats play a directional role in sports behavior, that is, echolocation.

Subsequently, the researchers used classic experimental devices and strict experimental design to verify whether the pigtail mouse has the ability of echolocation. Through the behavioral task experiment, it is found that the pigtail rats will spend more time and send out higher ultrasonic speed to explore the target. They can accurately detect the escape platform and successfully obtain food rewards in complete darkness. When its ears are blocked, the pig-tailed rat can’t receive the echo and can’t detect the target and complete the task; After removing the earplugs, the pig-tailed rat recovered its ability to explore and locate the target. Under the condition of eliminating vision, touch and controlling sense of smell, behavioral experiments confirmed that the pigtail mouse achieved its goal by emitting ultrasonic waves and receiving echoes by hearing.

In addition, the researchers used technical means to present the anatomical structure of the pig-tailed rat, and found that the spatial position of its hyoid bone and tympanic bone contacted and fused, which was consistent with the structure of the echolocation bat that sounded through the throat. This shows that the pig-tailed rat and the echolocation bat with laryngeal vocalization have the same anatomical structure basis in vocalization and auditory structure.

Liu Qi and other researchers also sequenced and assembled the high-quality whole genome of the Chinese pigtail mouse. Through evolutionary genomics analysis, it was found that the echolocation of the pigtail mouse originated independently. In the whole genome, the pig-tailed rat and the known echolocation species (bats and toothed whales) are significantly enriched in auditory genes.

By integrating several independent evidences of ethology, anatomy, genomics and gene function experiments, it is confirmed that the species of the genus Rodentia has the ability of echolocation.

It is expected to be used in artificial intelligence, blind-assisted navigation and other fields.

The echolocation ability of pigtailed rats seems to be inferior to that of ordinary people. However, Liu Qi said that this research may be applied to artificial intelligence in the future, such as improving auto-driving and blind-assisted navigation.

Liu Qi said that from the perspective of science itself, echolocation, as a special behavior of animals, is very rare in the animal kingdom. At present, the echolocation species known by human beings may be limited to a few kinds, such as bats and toothed whales, which are familiar to everyone, and some unfamiliar ones, such as some birds, shrews and hedgehogs.

"In addition to the animals listed above, we have confirmed that there is another kind of mouse, which also has echolocation skills. It is amazing in itself to find food or locate targets by hearing and ultrasound!" Liu Qi said that in addition to five groups of independent origin, such as bats, toothed whales and giant whales, the research team found a sixth group with this ability.

In addition, because the pig-tailed rat is a rodent, its genetic relationship and size are close to those of model animal mice, and its breeding is easy to operate, it is expected to become a new experimental animal to study the neural circuits of sound, hearing and echolocation.

Liu Qi said that human beings have developed many bionic products based on the long-term research on echolocation species such as bats. For example, bats will send out ultrasonic waves to detect targets, track moving prey, or avoid obstacles in time. The invented guide rod is convenient for the blind to move.

He admits that there is still a lot of room for the research and application of echolocation, and the research on bats, pigtails and other animals and their echolocation will have more influence on human life in the future.

After discovering that pigtail rats have echolocation ability, Liu Qi and his research team have been thinking about whether there are other nearly 6,000 kinds of mammals in nature that have this ability but have not been discovered. They hope that through the efforts of the team, they can find more such magical animals.

"This requires the unremitting efforts of many researchers, and it may even be a very long exploration process." Liu Qi said that the discovery of pig-tailed rat and its echolocation is only the beginning. They hope to stick to this research and expect that it can be used in artificial intelligence in the future, such as improving auto-driving and blind-assisted navigation.

(This article is from The Paper, please download the "The Paper" APP for more original information)

Tencent Cloud Industrial Internet Intelligent Industry Headquarters Settled in Liangjiang New District, Chongqing

  On August 23rd, a signing ceremony was held between Chongqing Liangjiang New Area and Tencent. The two parties jointly established Tencent Cloud Industrial Internet Intelligence Industry Headquarters to further promote the combination of intelligent industry in Chongqing Liangjiang New Area and Tencent Cloud’s technological advantages in the field of artificial intelligence, and help Chongqing Liangjiang New Area to build an innovative highland of industrial Internet and intelligent industry.

  Duan Chenggang, member of the Standing Committee of Chongqing Municipal Committee and secretary of the Party Working Committee of Liangjiang New Area, attended the event.

  Luo Lin, deputy secretary of the Party Working Committee and director of the Management Committee of Chongqing Liangjiang New Area, said in his speech that Chongqing Liangjiang New Area is the main host of the series of activities of Zhibo Fair and the city of wisdom in Chongqing. It will continue to play its leading role as an inland open gateway and a national-level new area, further promote digital industrialization and industrial digitalization, and strive to create a new situation of international cooperation in digital economy. The headquarters of Tencent Cloud Industrial Internet Intelligent Networking Project settled in Chongqing Liangjiang New Area, which is an important embodiment of Tencent and Chongqing Liangjiang New Area seizing opportunities and in-depth cooperation. It is believed that Tencent Cloud Industrial Internet, relying on the solid industrial foundation of Chongqing Liangjiang New Area, will surely lead the technological innovation, standard formulation and application promotion of industrial Internet, help build the whole industry chain ecology, and accelerate the application of industrial Internet innovation achievements. Chongqing Liangjiang New District will deepen pragmatic cooperation with Tencent Cloud in many fields, create a market-oriented, rule-of-law and international business environment with greater efforts, and provide high-quality, efficient and convenient services for enterprises.

  Tang Daosheng, senior executive vice president of Tencent, said that in the past year, Tencent Cloud has landed an industrial Internet base in Liangjiang New District of Chongqing, and has carried out extensive cooperation with enterprises, combining the power of digital technology with the needs of the real economy, consolidating the digital infrastructure, and opening up Tencent’s industrial Internet ecosystem. With its core location advantages and solid industrial foundation, Chongqing Liangjiang New Area has attracted a large number of investment enterprises, scientific research institutions and high-end talents to gather, which has given great support to Tencent and laid a very good foundation for Tencent Cloud to cooperate with Industry-University-Research. Tencent Cloud Industrial Internet Intelligent Industry Headquarters was established in Liangjiang New District of Chongqing, combining Tencent’s technological leading edge in the fields of cloud computing, big data and artificial intelligence with Chongqing’s intelligent industry strategy, and carrying out R&D, innovation and ecological layout of industrial intelligent products around enterprise intelligent manufacturing scenarios.

  It is reported that the joint establishment of Tencent Cloud Industrial Internet Intelligent Industry Headquarters is an important practice for Chongqing to accelerate the construction of a "smart town", and it is also the re-cultivation of Tencent Cloud in the field of industrial Internet.

  According to the agreement, in the future, Tencent Cloud Industrial Internet Intelligent Industry Headquarters will gather industrial Internet architects, R&D engineers, product and business team members, release industrial Internet intelligent product innovation, industrial Internet related standards or white papers, hold industrial Internet related standards meetings, and build a high-end influence in the industrial Internet field in Chongqing Liangjiang New Area.

  In terms of industrial Internet construction, we will give full play to Tencent Cloud’s advanced technology in the field of artificial intelligence, set up WeMake Industrial Internet Research Center, gather Tencent’s expert resources in the field of industrial Internet and Industry-University-Research Ecology, as the source of Tencent’s think tank to develop industrial Internet, conduct industrial Internet research and ecological collaborative innovation, and release Tencent’s latest research results and reports on industrial Internet.

  In terms of intelligent industry construction, R&D, innovation and ecological layout are carried out around the intelligent manufacturing scene of enterprises in Chongqing Liangjiang New Area. Through Tencent Cloud Industrial Internet Intelligent Industry Headquarters and the enterprises in Chongqing Liangjiang New Area, an industrial intelligent joint innovation lab is established, and industrial AI solutions and related patents are exported for the difficult and difficult scenes such as enterprise quality inspection, security, safe production, process upgrading and energy consumption optimization.

  Chongqing Liangjiang New District will take Tencent Cloud Industrial Internet Intelligent Industry Headquarters as the incubation platform, and carry out application innovation and industrial chain platform construction around "automobile, motorcycle and general machinery" (referred to as "automobile and motorcycle") vehicles and spare parts, so as to promote the digital upgrading of Chongqing’s "automobile and motorcycle" industry and help Chongqing build a new ecology of "automobile and motorcycle" industrial intelligence.

  The landing of Tencent Cloud Industrial Internet Intelligence Industry Headquarters will also vigorously promote the gathering of digital economy talents, technology, capital, data and other elements in Chongqing Liangjiang New District, and add new momentum to the construction of a national digital economy innovation and development experimental zone and a new generation of artificial intelligence innovation and development "dual core area" in the new district, which has become the core bearing area and application demonstration window for Chongqing to build a "smart town" and a "smart city".

  At the signing ceremony, Tencent Cloud Industrial Intelligent Brand and Tenghui Feiyu AI Quality Inspection Instrument were also held.

  Tenghui Feitong AI quality inspection instrument jointly built by Tencent Cloud and eco-partner Huiyan Technology is an artificial intelligence quality inspection integrated machine product that combines a number of AI algorithms and engineering innovations. Aiming at the problems of poor accuracy and low efficiency in appearance inspection of 3C parts and components, this product creatively adopts a one-stop intelligent solution, which can break through the bottleneck problem of manufacturing appearance inspection automation, greatly improve inspection efficiency, liberate quality inspection manpower and optimize costs.

  Li Shun, member of the Party Working Committee and Deputy Director of the Management Committee of Chongqing Liangjiang New Area, Pi Tao, member of the Party Working Committee and Deputy Director of the Management Committee of Chongqing Liangjiang New Area, Zhong Xiangping, Vice President of Tencent, Cai Guangzhong, Vice President of Tencent and General Manager of Tencent Southwest Area, and relevant responsible persons of Chongqing Liangjiang New Area and Tencent Company attended.

Shanxi’s intangible heritage protection and inheritance level has been continuously improved.

  Shanxi’s intangible cultural heritage is rich in resources, distinctive in characteristics and in good condition. The number of national intangible cultural heritage ranks third in China, with 182 national intangible cultural heritage representative projects and 149 national intangible cultural heritage representative inheritors. So many cultural treasures need not only to be included in the list, but also to "live" and ignite the intangible heritage with new thinking and methods, so that the intangible heritage can not only be protected, but also be inherited, developed, re-created and rejuvenated.

  Telling non-legacy stories, showing non-legacy skills, spreading non-legacy achievements, and exploring innovative development … On July 1st and 2nd, 36 teams from 22 universities in Shanxi Province told touching non-legacy stories. "This competition is an exploration of non-genetic inheritance. Students talk to the intangible heritage in their own way, and tell their stories in protecting and inheriting the intangible heritage in the form of stage play. With the thoughts and strength of youth, the traditional skills are given new vitality, showing the elegance and responsibility of contemporary young students. " The person in charge of the non-legacy office of the Provincial Cultural Tourism Department said.

  This competition is just a microcosm of Shanxi’s exploration of intangible heritage protection, inheritance and innovation. On March 22 this year, under the guidance of the Propaganda Department of the Provincial Party Committee, the Institute of Intangible Cultural Heritage, jointly established by Shanxi University and Shanxi Provincial Department of Culture and Tourism, was established to further promote the high-quality development of intangible cultural heritage protection in our province.

  Relying on the research institute, the Provincial Department of Culture and Tourism and Shanxi University jointly completed a number of non-legacy scientific research projects and non-legacy works. For the first time, the Institute launched the National Intangible Cultural Heritage Representative Project Shanxi Protection Achievements Series (10 volumes), and edited and published the annual blue book of Shanxi Intangible Cultural Heritage Protection and Inheritance-Shanxi Intangible Cultural Heritage Protection and Development Report (2022-2023). Complete a series of research reports, such as the investigation on the inheritance and protection of the characteristic folk art in the whole province, the investigation on the non-legacy tourism experience base in Shanxi, and the investigation on the national cultural and ecological protection zone in Jinzhong. In addition, the institute also innovatively carried out a wealth of non-legacy campus cultural activities: Shanxi University hosted the first campus speech contest of "Inheriting Non-legacy Youth at the Right Time" in the province; Established five excellent traditional cultural and artistic education bases, including Shanxi Opera Art and Culture, Xingyiquan and Shanxi Folk Dance; Fifteen excellent courses of "Non-legacy Shanxi" series have been opened, and Shanxi’s non-legacy characteristics and elements have been integrated into the ideological and political construction and aesthetic education.

  According to reports, in the "rejuvenation" and "rejuvenation" of intangible cultural heritage, Shanxi’s experience will be contributed to the systematic protection of national intangible cultural heritage, and the protection of intangible cultural heritage in our province will be exerted in three aspects.

  Effectively protect and consolidate the research work of intangible resources. Adhere to the principle of giving priority to protection, giving priority to rescue, rational utilization and inheritance and development, and improve the policy and regulation system and directory system for intangible protection. Do a good job in rescue, integrity, productivity and life protection. Strengthen the investigation and documentation of Shanxi intangible heritage and endangered projects and characteristic folk art projects. Understand the protection, inheritance, policy support and market development of various non-legacy projects, and explore measures to do a good job in non-legacy development.

  Inherit in an orderly way and promote the exploration of "non-legacy in the community". "Non-legacy in the community" is an effective path for the overall protection of non-legacy regions. Shanxi will strengthen the guidance of non-genetic inheritance, carry out regular learning activities, enrich the platform for non-legacy display, sink the units responsible for non-legacy protection to towns, streets, communities and villages, and focus on exploring the community rights and interests of non-legacy protection. The practice in Liujiabao Village, Liujiabao Township, xiaodian district, Taiyuan, Baiyangpo Village, Shicheng Town, Pingshun County, Changzhi City, Xiangfu Scenic Area of the Imperial City, Dayang Ancient Town Scenic Area, etc. has initially formed a successful model of benign interaction between intangible heritage and ancient towns, traditional villages and tourist attractions.

  Innovative and active, enriching new forms of expression of non-legacy words. Inspire the creativity of non-legacy innovation, and make the non-legacy culture "alive" with a young and fashionable way, a multi-dimensional perspective and rich and in-depth expression. Intensify efforts to carry out the work of Shanxi Intangible Cultural Heritage Shopping Festival, towns with intangible cultural heritage characteristics, intangible cultural heritage themed tourist routes, intangible cultural heritage workshops, intangible cultural heritage tourism experience bases and outstanding practical cases of intangible cultural heritage protection. Pay attention to the live transmission and contemporary expression of intangible cultural heritage, evaluate the relevance between intangible cultural heritage protection and people’s sense of life acquisition and cultural emotion, and constantly enhance the social influence and reputation of intangible cultural heritage. (Sun Rui)

Lingke 08 EM-P, with long battery life and strong power, won the championship in summer test.

In the wave of new energy vehicles, EM-P is like a bright star. With its super performance and super quality, it stood out in the summer test of major cars in 2024 and won many laurels, becoming the preferred car for many families.

Lectra 08 EM-P, as an outstanding representative of Lectra brand, is equipped with the leading EM-P super extended range electric scheme. This innovative technology has injected strong power into the LEICK 08, achieving a pure battery life of 245km and an excellent comprehensive battery life of 1400km. Whether you are traveling through the streets of the city or galloping on the vast long-distance road, Linke 08 can make your every trip full of confidence and peace of mind with stable performance and long endurance.

In this year’s summer test stage, LECK 08 EM-P has shown extraordinary strength. After strict testing by authoritative media such as China Automobile Center, car home, Know Car Emperor and Easy Car, it has won wide acclaim for its outstanding performance. In the high-temperature environment, the concentration of VOC and other harmful substances in Linke 08 is kept the lowest in the whole audience, creating a healthy and comfortable driving space for passengers. At the same time, in the extreme endurance test at high temperature, it also proved its excellent quality with amazing endurance.

Lingke 08 Time Limited Edition won the championship in the SUV lap speed list with a score of 02:19.87, which once again confirmed its extraordinary accomplishments in performance. In the easy-to-ride summer test, Lingke 08 topped the list of medium/medium-large hybrid groups of 150,000-300,000 with 72.7% endurance achievement rate, which fully demonstrated its excellent energy-saving strength.

The charm of Lectra 08 EM-P is not limited to performance and endurance. It is also equipped with an advanced Flyme Auto intelligent cockpit system to bring users a smooth and intelligent travel experience. At the same time, the intelligent driving computing platform equipped with Yikatong Tianqiao Pro provides the leading NOA pilot driving assistance function, which makes every driving easier and safer.

Choosing LECK 08 EM-P means choosing a driving experience and quality life beyond expectations. In this era of surging new energy vehicles, Linke 08 EM-P has won the favor of consumers with its excellent performance and quality, and has become a trustworthy travel partner.

It turns out that seals are so interesting that they have increased their knowledge!

When it comes to seals, I believe everyone will be familiar with them. Like walruses, they are all flippers, but the two hind flippers of seals can only bend backwards, so they can only crawl on land.

Seals spend most of their time in the sea. Their bodies are spindle-shaped and have short hairs all over their bodies. Their forelegs are shorter than their hind feet, and there are nails on these flippers. Seals also have ears, but their ears have become very small and can be opened and closed freely when swimming. They are good at swimming, and their hind feet are like divers’ fins, which can swing back and forth in the water and move forward quickly. Seals dive for a long time, usually up to more than half an hour. When diving underwater, their heart rate will drop very low, which can reduce oxygen consumption.

Most seals live in cold waters, but they are not afraid of the cold, because they have a thick layer of fat, so seals usually like to live in places with ice in the North or South Pole. Seals also live in some sea areas of China, such as Bohai Sea. These sea areas freeze every winter, especially in Liaodong Bay and ice period for 130 days. These thick ice layers are inaccessible, and seals thrive here, the most of which are spotted seals.

These spotted seals are small, generally only 1.5 to 2 meters long. The maximum weight of males is 150 kilograms, while females are slightly smaller, about 100 kilograms. Their biggest feature is that their backs are covered with irregular brown-gray or brown-black spots, hence the name of spotted seals. They are very cute, so they are also permanent residents of the aquarium.

In the seal society, polygamy is practiced, so the number of wives and concubines usually depends on the male seal’s own physique. In order to compete for females, males often fight. Seals fight a bit like sumo. They use their hind legs to support themselves and try their best to pounce on each other. Sometimes seals will bite each other’s fur and blood will flow. At the end of the battle, the winner wins the right to mate, while the loser can only continue to look for the next female seal.

In early spring, baby seals will be born. At this time, we can see a young seal lying next to the female seal, which is very interesting. The young seal is raised by both parents, and the female seal is fed several times a day. Of course, the mother seal will only breast-feed her baby. If other baby seals come near, they will be rudely driven away. Some people may think that the mother seal is selfish, but this may be the law of nature.

The fat content in seal milk is very high, so baby seals will grow very fast. Young seals don’t have a thick layer of fat, but their hair is very fluffy and soft, and baby seals rely on these hairs to keep warm. But fluffy hair makes it inconvenient for them to swim, so baby seals rarely go into the water during lactation. Most of the fur of baby seals is white. From a distance, it is like snow, which is not easy to be found. They are not afraid of the cold and live a very leisurely life.

The lactation period of seals is not long, especially spotted seals, which only lasts for one month. After lactation, the mother seal will become skinny, and they will leave their children to recover. At this time, the seal family will end and the baby seal will begin to live independently in the water.

The leathers of seals are tough, comparable to cowhide, and can be processed into purses and leather shoes. Their thick fat can extract oil, and their meat is edible and has high nutritional value. In addition, the testicles of male seals are valuable Chinese herbal medicines, which have the effects of enriching blood and strengthening yang, and their livers are valuable tonics. Seals are all treasures, so they have always been the target of human hunting. Every spring, seals go ashore. In the 19th century, many countries used well-equipped ships to catch seals in the Antarctic, among which the crab-eating seals were the most caught. These hunting teams kill seals like crazy, and they can get tens of thousands of leopard skins from South Georgia in just one season.

Before the 1980s, fishermen along the Bohai Sea in China also had a tradition of killing spotted seals, but later legislation prohibited the killing of spotted seals, and now the population has recovered. In 2009, EU legislated to ban the trade of seal products, and Russia also banned the commercial seal slaughter.

Luzhou area eπ 008 special sale, discount 28,000! not to be missed

[Autohome Luzhou Discount Promotion Channel] brings you the latest news, a large-scale promotion is being carried out in the Luzhou area, which has attracted much attention. This car purchase discount is unprecedented, with a maximum discount of 28,000 yuan, bringing real economic benefits to car buyers. The starting price has been reduced to 188,600 yuan, which is very competitive. If you are interested in eπ 008, don’t miss this great opportunity, click "Check the car price" in the quotation form, and strive to get more favorable car purchase conditions within a limited time.

泸州地区eπ008特价出售,优惠2.8万!不容错过

The Eπ 008 is a car that combines futuristic and technological charm. The front face is uniquely designed, and the exquisite air intake grille is like a little starlight in the galaxy, showing its unique recognition. The overall style is simple and streamlined, with smooth lines, giving people a dynamic and dynamic visual experience, reflecting the pursuit of fashion and efficiency.

With its unique side lines, the eπ 008 outlines an elegant and dynamic profile. The body size is 5002mm x 1972mm x 1732mm, and the wheelbase is up to 3025mm, ensuring a spacious interior and stable driving performance. The front and rear wheelbases are both 1650mm, demonstrating a first-class sense of balance. In terms of tire specifications, the eπ 008 uses 265/45 R21 high-performance tires, paired with a delicate rim design, which not only enhances the visual impact of the vehicle, but also provides the driver with excellent grip and handling.

泸州地区eπ008特价出售,优惠2.8万!不容错过

内饰方面,eπ008采用了现代简约的设计风格,以精致与科技感为特点。宽敞的车内空间中,方向盘采用了皮质材料,握感舒适且支持手动上下及前后调节,满足驾驶者的个性化需求。15.6英寸的中控屏幕矗立中央,集多媒体、导航与电话功能于一体,同时具备语音识别控制,操作便捷且智能化。座椅采用仿皮材质,提供良好的触感和支撑,主副驾驶座椅支持多向调节,包括前后、靠背、高低以及腰部支撑,满足不同乘客的舒适需求。同时,前排座椅还配备了加热和通风功能,以及电动座椅记忆功能,照顾到驾驶者的日常使用体验。第二排座椅同样支持前后调节和靠背调节,且配备腿托调节,确保长途乘坐的舒适性。后排座椅支持比例放倒,为行李空间的灵活性提供了便利。

泸州地区eπ008特价出售,优惠2.8万!不容错过

车系eπ008搭载的是一款1.5T涡轮增压发动机,其最大功率达到了108千瓦,最大扭矩为210牛·米,提供147马力的动力输出。匹配的是一款电动车单速变速箱,确保了车辆的顺畅行驶和高效性能。

综上所述,汽车之家车主对eπ008的外观设计赞赏有加,认为其低风阻系数带来的回头率不容忽视。然而,他也提到了一些实际使用中的小问题,如漆面易损和车标可能的掉漆问题。他建议潜在车主在提车时仔细检查,尤其是车顶部分。虽然车头造型可能不显霸气,但车主认为其蠢萌的风格也别具一格。在体验了车尾MPV风格和流媒体后视镜的设计后,他认为这些细节都为eπ008增添了独特的魅力。尽管存在一些小瑕疵,但整体来看,车主@啦啦啦大嘎嘎对eπ008的满意度依旧显著。

Nicholas Tse responded whether he would cooperate with Faye Wong on filming: Definitely not

On March 14, Nicholas Tse appeared at the 2023 Emperor Film Tour to promote a number of new plays. When asked by reporters about Faye Wong, he kept silent. When he talked about his girlfriend Faye Wong accompanying him back to Hong Kong, he prevaricated on the grounds of "please tell me about the movie". Asked if he would cooperate with Faye Wong in the play, Nicholas Tse flatly refused: "Definitely not".

Nicholas Tse responded whether he would cooperate with Faye Wong on filming: Definitely not

Night reading, a man with a history of drug abuse was involved in theft and was caught while watching "Operation Ice Breaking". "Wayward Brother" carried 81 sacks 140,000 coins to buy a car

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"I paid 70,000 multiple car purchases, but now I don’t get the car, and I can’t even get this car purchase back." Recently, Mr. Su of Hechuan reported to the upstream news hotline 966966/upstream news APP that he was happy to buy a car, but he had such a thing. In order to get this car purchase back in the past few days, he has traveled back and forth to Chongqing several times.

Paid 70,000 down payment and was told there was no car

Last month, Mr. Su spotted an SUV at the Lynk & Co car sales showroom on Shixin Road in Jiulongpo District. On May 18, he deposited the down payment of 73,800 yuan into the account of the dealer Chongqing Century Jinye Automobile Sales Company. "At that time, the salesperson said that there was a 2019 model, and I paid for it." When Mr. Su handled the pickup, he found that the car that the other party planned to give him was not a 2019 model, but a 2018 model.

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Car purchase receipt.

"So I asked for a refund, and the other party agreed, but it never materialized." Mr. Su said that on May 23 and 24, he stayed at the 4S store for two days, but it was not properly resolved. The staff even said that the refund was not available, and the car could not be given even the old car. After that, Mr. Su went to the dealer to negotiate many times, but there was no result.

On the afternoon of May 27, the reporter and Mr. Su arrived at the 4S store. The light in the exhibition hall was dim, and the staff said that due to a power outage, they had a day off temporarily, and the person in charge was not there.

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There was a power outage in the 4S store on the day of the interview.

During the interview, several staff members kept quiet about the matter and refused to provide the contact information of the person in charge. After repeated inquiries from reporters, one staff member admitted that he had indeed said that he could refund Mr. Su. "How long will it take to get the money?" The reporter asked, but the staff member did not reply.

The security deposit of the second-level dealer cannot be recovered either.

In the interview, the reporter learned that several other car buyers and secondary dealers have encountered similar experiences.

"The car is not given, the money is not refunded, and I am not the only one who has been deceived by this 4S store. The most excessive thing is that the store is still operating normally in the morning." Mr. Su provided reporters with the contact information of another activist, who he said had raised a banner outside the store a few days ago.

"There is indeed such a thing, I am a second-level dealer in Rongchang, and I need a few display cars, so I ordered three cars in the store, signed the contract in April, and paid a 150,000 yuan security deposit." By mid-May, the activist said, the company asked them to return the cars to the store due to internal equity issues.

What he didn’t expect was that after returning three cars and going through all the formalities, he couldn’t get the security deposit back. "We’ve been here a few times, but the boss just dragged it on anyway, and then we called the police, and the police asked us to sue, but the process was too long." The activist said helplessly that he could only continue to urge the other party to refund the security deposit.

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A group of activists has been established.

Lawyers offer a variety of avenues for defending their rights

In the face of this situation, how should consumers protect their rights? Chongqing Zhitong (Liangjiang New District) Law Firm, lawyer Yue Hongwu, believes that there are many ways for consumers to protect their rights. First, consumers can directly negotiate with the manager, and if the company manager delays or has no right to resolve, they can directly consult with the company’s leaders. Second, if the negotiation fails, consumers can also seek help from the consumer rights association where the other company is located. Third, consumers can also file complaints and appeals with the local market supervision department. Fourth, consumers can also directly apply to arbitration institutions or people’s courts for arbitration and litigation, and at the same time take preservation measures to freeze and seal the company’s property and promptly protect their rights.

The lawyer said that in the case of Mr. Su, the car sales company violated the contract to provide other models of vehicles, and said that the company did not have such vehicles and refused to replace them, which was suspected of fraud. Mr. Li could actively take up legal weapons to safeguard his legitimate rights and interests.

Upstream News Reporter, Wang Yizhu, Text/Photo/Video

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